This is an archived copy of the 2023-24 guide. To access the most recent version of the guide, please visit http://guide.berkeley.edu.
About the Program
Bachelor of Arts (BA)
The undergraduate major in Molecular and Cell Biology (MCB) focuses on the study of molecular structures and processes of cellular life and their roles in the function, reproduction, and development of living organisms. This covers a broad range of specialized disciplines, such as biochemistry, microbiology, biophysics, molecular biology, genetics, cell physiology, cell anatomy, immunology, and neurobiology. The types of living organisms from which the departmental faculty draws its working materials are as diverse as its disciplinary concentrations, ranging from viruses and microbes through plants, roundworms, annelids, arthropods, and mollusks, to fish, amphibia, and mammals.
All of the emphases except Neurobiology have multiple tracks to choose from. Some tracks only differ slightly and some give a whole different perspective on the emphasis. For help deciding your emphasis please see a staff or peer advisor in MCB!
Declaring the Major
Students can receive pre-major advising at any time from staff or peer advisors. MCB will accept any interested student who meets the minimum course and GPA requirements and is realistically able to complete the major requirements during the student's time at UC Berkeley. Any student intending to major in MCB must finish declaring or complete MCB conditions to declare by the end of their 6th semester, or during the semester before their graduating term (if this semester is before their 6th semester).
In order to declare the MCB major, students must have completed or be enrolled in BIOLOGY 1A/BIOLOGY 1AL (with a C or better on the first Bio 1A midterm) and CHEM 3B (past the early drop deadline), have at least a 2.0 overall GPA, a 2.0 GPA in all courses taken for the major, a 2.0 GPA in any upper division courses taken for the major, and choose an emphasis. Intended MCB students are not required to have completed the math, physics, or Bio 1B requirements at the time of declaration (though these requirements must be met in order to graduate).
Once the declaration form has been processed, students will receive an email with instructions to schedule an appointment to meet with a staff advisor. Advising appointments take place either online on Zoom or in person at the Undergraduate Advising Office in 3060 Valley Life Sciences Building. See full instructions on the MCB Declaration page.
In addition to the University, campus, and college requirements, listed on the College Requirements tab, students must fulfill requirements specific to their major program and declared emphasis.
All courses taken to fulfill the major requirements below must be taken for letter-graded credit.
No more than one upper division course may be used to simultaneously fulfill requirements for a student's major and minor programs. Double majors and simultaneous degrees are limited to a two-course overlap.
Students must maintain a minimum grade point average (GPA) of at least a 2.0 GPA overall, a 2.0 GPA in the required major coursework (lower and upper division), and a 2.0 GPA in the upper division coursework for the major.
For information regarding residency requirements and unit requirements, please see the College Requirements tab.
Lower Division Requirements for All Emphases
Please note the alternative chemistry sequence for BBS Track 2.
Undergraduate students must fulfill the following requirements in addition to those required by their major program.
For detailed lists of courses that fulfill college requirements, please review the College of Letters & Sciences page in this Guide. For College advising appointments, please visit the L&S Advising Pages.
All students who will enter the University of California as freshmen must demonstrate their command of the English language by fulfilling the Entry Level Writing requirement. Fulfillment of this requirement is also a prerequisite to enrollment in all reading and composition courses at UC Berkeley.
The American History and Institutions requirements are based on the principle that a US resident graduated from an American university, should have an understanding of the history and governmental institutions of the United States.
All undergraduate students at Cal need to take and pass this course in order to graduate. The requirement offers an exciting intellectual environment centered on the study of race, ethnicity and culture of the United States. AC courses offer students opportunities to be part of research-led, highly accomplished teaching environments, grappling with the complexity of American Culture.
College of Letters & Science Essential Skills Requirements
The Quantitative Reasoning requirement is designed to ensure that students graduate with basic understanding and competency in math, statistics, or computer science. The requirement may be satisfied by exam or by taking an approved course.
The Foreign Language requirement may be satisfied by demonstrating proficiency in reading comprehension, writing, and conversation in a foreign language equivalent to the second semester college level, either by passing an exam or by completing approved course work.
In order to provide a solid foundation in reading, writing, and critical thinking the College requires two semesters of lower division work in composition in sequence. Students must complete parts A & B reading and composition courses in sequential order by the end of their fourth semester.
College of Letters & Science 7 Course Breadth Requirements
The undergraduate breadth requirements provide Berkeley students with a rich and varied educational experience outside of their major program. As the foundation of a liberal arts education, breadth courses give students a view into the intellectual life of the University while introducing them to a multitude of perspectives and approaches to research and scholarship. Engaging students in new disciplines and with peers from other majors, the breadth experience strengthens interdisciplinary connections and context that prepares Berkeley graduates to understand and solve the complex issues of their day.
Unit Requirements
120 total units
Of the 120 units, 36 must be upper division units
Of the 36 upper division units, 6 must be taken in courses offered outside your major department
Residence Requirements
For units to be considered in "residence," you must be registered in courses on the Berkeley campus as a student in the College of Letters & Science. Most students automatically fulfill the residence requirement by attending classes here for four years, or two years for transfer students. In general, there is no need to be concerned about this requirement, unless you go abroad for a semester or year or want to take courses at another institution or through UC Extension during your senior year. In these cases, you should make an appointment to meet an adviser to determine how you can meet the Senior Residence Requirement.
Note: Courses taken through UC Extension do not count toward residence.
Senior Residence Requirement
After you become a senior (with 90 semester units earned toward your BA degree), you must complete at least 24 of the remaining 30 units in residence in at least two semesters. To count as residence, a semester must consist of at least 6 passed units. Intercampus Visitor, EAP, and UC Berkeley-Washington Program (UCDC) units are excluded.
You may use a Berkeley Summer Session to satisfy one semester of the Senior Residence requirement, provided that you successfully complete 6 units of course work in the Summer Session and that you have been enrolled previously in the college.
Modified Senior Residence Requirement
Participants in the UC Education Abroad Program (EAP), Berkeley Summer Abroad, or the UC Berkeley Washington Program (UCDC) may meet a Modified Senior Residence requirement by completing 24 (excluding EAP) of their final 60 semester units in residence. At least 12 of these 24 units must be completed after you have completed 90 units.
Upper Division Residence Requirement
You must complete in residence a minimum of 18 units of upper division courses (excluding UCEAP units), 12 of which must satisfy the requirements for your major.
Plans of Study
Sample four-year plans are available on the Molecular & Cell Biology department website for each emphasis (concentration):
The Department of Molecular and Cell Biology (MCB) is a large department that is subdivided into five divisions: Biochemistry, Biophysics & Structural Biology (BBS); Cell Biology, Development & Physiology (CDP); Genetics, Genomics, Evolution, and Development (GGED); Immunology & Molecular Medicine (IMM); Molecular Therapeutics (MTX) and Neurobiology (NEU). All MCB students complete the same lower-division coursework to gain critical training in biology, mathematics, chemistry, and physics (except for BBS track 2 Biological Chemistry, please see the MCB website for details). Most lower-division coursework is completed before the major declaration. Upon declaring the major, MCB students choose an emphasis and track, which determines the upper-division core courses they will take and elective choices from which they will choose. Students can choose among several areas of specialization; emphases are broadly defined along divisional lines and allow students to focus on a more defined topic within MCB. MCB students who elect to participate in independent research may choose from sponsoring research laboratories within any MCB division, or in laboratories outside the department (other Berkeley departments, LBNL, CHORI, UCSF, biotechnology companies). The MCB major provides excellent preparation for many careers and post-baccalaureate training programs, including graduate programs and health-related professional programs (e.g., medicine, dentistry, optometry, pharmacy), science writing, law school, biotechnology, teaching, and academic research.
Learning Goals for the Major
Describe basic biological concepts and principles.
Appreciate the different levels of biological organization, from molecules to ecosystems.
Understand that biology has a chemical, physical, and mathematical basis.
Explain the importance of the scientific method to understanding natural phenomena.
Effectively communicate scientific data and ideas, both orally and in writing.
Critically evaluate data, develop a hypothesis, and design experiments to address an interesting and novel problem.
Demonstrate advanced knowledge in a specialized field of molecular and cell biology.
Major Map
Major Maps help undergraduate students discover academic, co-curricular, and discovery opportunities at UC Berkeley based on intended major or field of interest. Developed by the Division of Undergraduate Education in collaboration with academic departments, these experience maps will help you:
Explore your major and gain a better understanding of your field of study
Connect with people and programs that inspire and sustain your creativity, drive, curiosity and success
Discover opportunities for independent inquiry, enterprise, and creative expression
Engage locally and globally to broaden your perspectives and change the world
Reflect on your academic career and prepare for life after Berkeley
Use the major map below as a guide to planning your undergraduate journey and designing your own unique Berkeley experience.
MCB offers three types of undergraduate advising: staff advisers, faculty advisors, and peer advisors.
Staff Advisers
Staff academic advisors (aka Major Advisors) are trained to support students and assist them in successfully completing their MCB major. They are excellent resources for questions concerning administration and academics, or finding out about other available services. Students should see a staff adviser for the following:
Ask questions about major requirements.
Ask for advice about schedule planning.
Declare the MCB major.
Consult about research opportunities, graduate and professional schools, career opportunities, scholarships, and internships.
Get information about research and enroll in research units.
Request general assistance, advice, or information.
Find out about upcoming events and programs.
Staff advisers are available for pre-scheduled appointments and short-notice appointments for specific services. If students would like to schedule an appointment, they can review their scheduling options on our Advising Services page for more information.
The general email address is mcbuao@berkeley.edu which is checked daily, Monday through Friday.
Faculty Advisers
Faculty advisors are MCB professors assigned to advise students about the MCB department, its courses, its research, and other academic issues. Students typically first meet with a faculty advisor when they declare an MCB major. Students should see their faculty advisers for the following:
Receive guidance toward achieving academic and career goals.
Ask questions about the content of MCB courses.
Ask questions about biological research and about the field of biology in general.
Ask for recommendations on which graduate schools to attend.
Review and approve the major declaration plans after speaking with a UAO staff adviser.
For a list of advisors and their office hours, please see the department's website. Faculty adviser office hours are effective from the first day of instruction until the final day of instruction for the fall and spring semesters. Faculty advisers are not available for office hours during winter or summer break.
Peer Adviser Walk-in Services (PAWS)
Peer advisers are junior and senior MCB majors who volunteer their time to complement the UAO advising services by sharing their knowledge of and experience with lower-division requirements and upper-division classes, experience with student groups on campus, preparation for life beyond the BA, and use of various campus resources. To see the schedule and more information about who the peer advisers are and which courses they have taken, click here.
Academic Opportunities
Undergraduate Research
Under the guidance of a faculty member and/or research mentor, undergraduates in the MCB major may have the opportunity to work in a laboratory to gain valuable experience in scientific research. Interested students must take the initiative to make such arrangements. Over 70 % of MCB students work in a lab to gain valuable experience in scientific research. To get started, students should talk with classmates, peer advisers, a staff undergraduate adviser, graduate student instructors (GSIs), and faculty about their interest in learning more about laboratory research. For more information on research, see How to Find a Lab Position.
Benefits of research:
Science is a way to figure things out, so doing research will aid students in other aspects of their life. Students will ask and answer open-ended questions and link seemingly disconnected pieces of information to find results that were not predicted.
Explore things at the cutting edge and that no one has explored before.
Learn tenacity, problem-solving, and to be critical about the details because things have to be reproducible.
Solve mysteries and experience the excitement of discovery.
Students may receive academic credit for their work by enrolling in an independent study course: MCELLBI 99/MCELLBI 199/MCELLBI 191 or MCELLBI H196A/MCELLBI H196B. Enrollment applications are due in the Undergraduate Advising Office by the fifth week of each semester.
Honors Program
The MCB honors program offers exceptional senior students recognition for outstanding academic achievement and excellence in research. To graduate with honors in the major, students must satisfy the following:
Complete at least two credited semesters of research including four to eight units of MCELLBI H196A and/or MCELLBI H196B (Honors Research).
Have a cumulative Berkeley grade point average (GPA) of at least 3.5 in all work completed at UC Berkeley.
Have at least a 3.5 GPA in the MCB major requirements or 3.5 GPA in MCB upper-division courses.
Present their research in an approved forum, such as an MCB symposium, the Undergraduate Poster Session, or other scientific meeting.
Write an honors thesis approved by an MCB faculty sponsor.
Additional information on the honors program is available in the Undergraduate Affairs Office and on the MCB website.
Other Research Opportunities
For additional resources for information regarding research opportunities, please see the links below:
Terms offered: Spring 2024, Spring 2023, Spring 2022
Students in this course will critically examine modern methods of biological investigations and their social implications. Relevant literature will be used to present basic biological concepts that address the cultural, technological and health aspects of current topics in the biological sciences. Designing and evaluating scientific questions will be stressed. Current Topics in the Biological Sciences: Read More [+]
Rules & Requirements
Prerequisites: Suitable for freshmen who plan to major in a biological science
Repeat rules: Course may be repeated for credit when topic changes.
Hours & Format
Fall and/or spring: 15 weeks - 2 hours of lecture and 1 hour of discussion per week
Additional Details
Subject/Course Level: Molecular and Cell Biology/Undergraduate
Grading/Final exam status: Letter grade. Final exam not required.
Terms offered: Fall 2024, Spring 2024, Fall 2023
The Berkeley Seminar Program has been designed to provide new students with the opportunity to explore an intellectual topic with a faculty member in a small-seminar setting. Berkeley Seminars are offered in all campus departments, and topics vary from department to department and semester to semester. Final assessment to be decided by the instructor when the class is offered. Freshman Seminars: Read More [+]
Rules & Requirements
Prerequisites: Open to freshmen only
Repeat rules: Course may be repeated for credit without restriction.
Hours & Format
Fall and/or spring: 15 weeks - 1 hour of seminar per week
Additional Details
Subject/Course Level: Molecular and Cell Biology/Undergraduate
Grading/Final exam status: The grading option will be decided by the instructor when the class is offered. Alternative to final exam.
Terms offered: Spring 2014, Spring 2012
An introduction for students who do not intend to major in biology but who wish to satisfy their breadth requirement in Biological Sciences. Some major concepts of modern biology, ranging from the role of DNA and the way cells communicate, to interactions of cells and creatures with their environment, will be discussed without jargon and with attention to their relevance in contemporary life and culture. Big Ideas in Cell Biology: Read More [+]
Hours & Format
Fall and/or spring: 15 weeks - 2 hours of lecture and 1 hour of discussion per week
Additional Details
Subject/Course Level: Molecular and Cell Biology/Undergraduate
Grading/Final exam status: Letter grade. Final exam required.
Terms offered: Fall 2024, Summer 2024 8 Week Session, Fall 2023
A comprehensive introduction to human biology. The course will concentrate on basic mechanisms underlying human life processes, including cells and membranes; nerve and muscle function; cardiovascular, respiratory, renal, and gastrointestinal physiology; metabolism, endocrinology, and reproduction. Introduction to Human Physiology: Read More [+]
Rules & Requirements
Prerequisites: One year high school or college chemistry
Hours & Format
Fall and/or spring: 15 weeks - 3 hours of lecture and 1 hour of discussion per week
Summer: 8 weeks - 6 hours of lecture and 2 hours of discussion per week
Additional Details
Subject/Course Level: Molecular and Cell Biology/Undergraduate
Grading/Final exam status: Letter grade. Final exam required.
Terms offered: Fall 2024, Summer 2024 Second 6 Week Session, Fall 2023
Experiments and demonstrations are designed to amplify and reinforce information presented in 32. Exercises include investigations into the structure and function of muscle, nerve, cardiovascular, renal, respiratory, endocrine, and blood systems. Introduction to Human Physiology Laboratory: Read More [+]
Rules & Requirements
Prerequisites: 32 or may be taken concurrently
Hours & Format
Fall and/or spring: 15 weeks - 1 hour of lecture and 3 hours of laboratory per week
Summer: 6 weeks - 2 hours of lecture and 8 hours of laboratory per week 8 weeks - 2 hours of lecture and 6 hours of laboratory per week
Additional Details
Subject/Course Level: Molecular and Cell Biology/Undergraduate
Grading/Final exam status: Letter grade. Final exam not required.
Terms offered: Spring 2024, Spring 2023, Spring 2022
Innovations in bioengineering and use of stem cells will significantly impact our ability to combat human disease, genetic disorders and physiological dysfunction. An understanding of human stem cell biology will be critical to make informed decisions on our health and public policy. Stem Cell Biology, Ethics and Societal Impact: Read More [+]
Rules & Requirements
Repeat rules: Course may be repeated for credit with instructor consent.
Hours & Format
Fall and/or spring: 15 weeks - 3 hours of lecture and 1 hour of discussion per week
Additional Details
Subject/Course Level: Molecular and Cell Biology/Undergraduate
Grading/Final exam status: Letter grade. Final exam required.
Terms offered: Spring 2016, Spring 2013, Summer 2012 8 Week Session
Basic communication of inheritance; gene mapping; gene expression and genetic disease in animals and humans; social inheritance of genetics. Genetics and Society: Read More [+]
Rules & Requirements
Prerequisites: Primarily for students not specializing in biology
Credit Restrictions: Students will receive no credit for Molecular and Cell Biology 41 after completing Biology 1A, Biology 1B, or Letters and Science 18.
Hours & Format
Fall and/or spring: 15 weeks - 2 hours of lecture and 1 hour of discussion per week
Summer: 6 weeks - 7.5 hours of lecture per week 8 weeks - 6 hours of lecture and 2 hours of discussion per week
Additional Details
Subject/Course Level: Molecular and Cell Biology/Undergraduate
Grading/Final exam status: Letter grade. Final exam required.
Terms offered: Spring 2017, Spring 2015, Spring 2014
This is a Discovery Course for non-Biology majors designed to introduce lower-division college students to biology through the lens of the contemporary problems facing people, the planet and the species of the planet. Modern genetic contributions will be presented on such issues as genetic engineering of plants and animals, the emergence of new pathogens, the role of genetic variation among individuals, and the extent to which DNA is and isn’t destiny. Each week will close with the presentation and discussion of a defining biological challenge facing the world. Biology for Voters: Read More [+]
Objectives & Outcomes
Student Learning Outcomes: The learning objectives will be, at one end, to understand what an experiment is, how is it controlled and what does one need to know about an experiment to be able to rely upon any conclusion. That is the fundamental issue in all science, and is frequently overlooked in many media accounts of science. A second objective is to learn enough of the language of biology to be able to ask the kind of informed questions that we would want all elected representatives to pay attention to. A third objective is for students to cultivate confidence that through non-specialized information sources they can become informed consumers of contemporary scientific thought, and to develop those habits of intellect to think about evidence in a scientific manner. A fourth objective is for students to enjoy the abundance of high quality books, articles and multimedia that will enable a lifetime of discovery outside the structure of a college course.
Hours & Format
Fall and/or spring: 15 weeks - 3 hours of lecture and 1 hour of discussion per week
Additional Details
Subject/Course Level: Molecular and Cell Biology/Undergraduate
Grading/Final exam status: Letter grade. Final exam required.
Terms offered: Spring 2024, Spring 2023, Spring 2022
Course will discuss how the immune system resolves, prevents, or causes disease. A general overview of the immune system will be covered in the first five weeks followed by five weeks discussing infectious diseases including anthrax, mad cow, herpes, malaria, tuberculosis, and HIV. In addition, other lectures will focus on current immunology topics including vaccines, autoimmunity, allergy, transplantation, and cancer. The Immune System and Disease: Read More [+]
Rules & Requirements
Prerequisites: High school chemistry or Chemistry 1A and high school biology or Biology 1A. Biology 1AL is not required
Credit Restrictions: Students will receive no credit for Molecular and Cell Biology 50 after completing Molecular and Cell Biology 102, C100A/Chemistry C130, or Chemistry 135.
Hours & Format
Fall and/or spring: 15 weeks - 3 hours of lecture and 1 hour of discussion per week
Additional Details
Subject/Course Level: Molecular and Cell Biology/Undergraduate
Grading/Final exam status: Letter grade. Final exam required.
Terms offered: Fall 2024, Summer 2024 Second 6 Week Session, Fall 2023
Discussion of how infectious agents cause disease and impact society at large. We will examine historical and current examples of plagues and pandemics and consider the question of what we should do to ameliorate the impact of infectious disease in the future. The course is intended for non-majors and will begin by briefly providing necessary background in microbiology and immunology. The primary focus in each subsequent week, however, will be on discussing a particular infectious disease. The course will be broad in scope covering biological, historical, ethical and social implications of each disease. Plagues and Pandemics: Read More [+]
Terms offered: Summer 2019 Second 6 Week Session
This lab course is an introduction to mammalian neuroanatomy for non-MCB majors. We will do dissections, explore physical anatomical models, and observe microscopic structures within preserved brain slices from a variety of mammalian species. The hands-on exploration of anatomy is key to understanding how the different functional regions of the nervous system are interconnected. Besides gaining a better understanding of anatomy, you will gain important scientific skills such as conducting parts of a neurological exam, fluorescent and light microscopy, reading MRI scans and conducting fine dissections. The course will culminate with a group project using the online Allen Brain Atlas to investigate a novel scientific question. Introduction to Neuroanatomy Lab: Read More [+]
Rules & Requirements
Prerequisites: MCELLBI 63 (may be taken concurrently) or equivalent
Credit Restrictions: Students will receive no credit for Molecular and Cell Biology 63L after taking Molecular and Cell Biology 160L or 163L
Hours & Format
Summer: 6 weeks - 8 hours of laboratory per week
Additional Details
Subject/Course Level: Molecular and Cell Biology/Undergraduate
Grading/Final exam status: Letter grade. Alternative to final exam.
Terms offered: Spring 2019
This course offers an introduction to the field of biotechnology and will cover the history of the field, its impact on medicine and society, key methodologies, important therapeutic areas, and the range of career options available in the biopharmaceutical industry. In addition to lectures on innovation and entrepreneurship, students will hear from lecturers with expertise ranging from molecular biology to clinical trial design and interpretation. Several case studies of historically impactful scientists, entrepreneurs, and biotherapeutic companies will be presented. Students will work in teams to create and develop novel biotechnology company ideas to present in class. Intended for students interested in the Biology+Business program. Introduction to the Biotechnology Field and Industry: Read More [+]
Hours & Format
Fall and/or spring: 15 weeks - 2 hours of lecture per week
Additional Details
Subject/Course Level: Molecular and Cell Biology/Undergraduate
Grading/Final exam status: Offered for pass/not pass grade only. Alternative to final exam.
Instructors: Kirn, Lasky
Formerly known as: Molecular and Cell Biology C95B/Undergrad. Business Administration C95B
Terms offered: Fall 2013, Spring 2013, Fall 2012
Sophomore seminars are small interactive courses offered by faculty members in departments all across the campus. Sophomore seminars offer opportunity for close, regular intellectual contact between faculty members and students in the crucial second year. The topics vary from department to department and semester to semester. Enrollment limited to 15 sophomores. Sophomore Seminar: Read More [+]
Rules & Requirements
Prerequisites: At discretion of instructor
Repeat rules: Course may be repeated for credit without restriction.
Hours & Format
Fall and/or spring: 15 weeks - 1-2 hours of seminar per week
Summer: 6 weeks - 4-6 hours of seminar per week 8 weeks - 3-4 hours of seminar per week
Additional Details
Subject/Course Level: Molecular and Cell Biology/Undergraduate
Grading/Final exam status: The grading option will be decided by the instructor when the class is offered. Final exam required.
Terms offered: Spring 2018, Spring 2017
We will work with a variety of datasets that describe a molecular view of cells and how they divide. We will learn about the processes that cause cells to become specialized (differentiate) and to give rise to cancer (transform). We will analyze data on genetic mutations in cancer that distinguish tumor cells from normal cells. We will learn how mutations are detected by the immune system and the basis of cancer immunotherapy. Finally we will analyze data on clinical trials of cancer immunotherapy to define the correlates of success in curing the disease. The students are expected to gain an understanding of data that reveals the basics of cell physiology and cancer, how immunotherapies of cancer work and their current limitations. Immunotherapy of Cancer: Success and Failures: Read More [+]
Terms offered: Fall 2024, Fall 2023, Fall 2022
Students will be introduced to the "culture" of the biological sciences, along with an in-depth orientation to the academic life and the culture of the university as they relate to majoring in biology. Students will learn concepts, skills, and information that they can use in their major courses, and as future science professionals. Studying the Biological Sciences: Read More [+]
Rules & Requirements
Prerequisites: Consent of instructor
Hours & Format
Fall and/or spring: 15 weeks - 2 hours of lecture per week
Additional Details
Subject/Course Level: Molecular and Cell Biology/Undergraduate
Grading/Final exam status: Offered for pass/not pass grade only. Final exam required.
Terms offered: Fall 2023, Spring 2023, Fall 2022
Lectures and small group discussions focusing on topics of interest, varying from semester to semester. Directed Group Study: Read More [+]
Rules & Requirements
Prerequisites: Freshmen and sophomores only
Repeat rules: Course may be repeated for credit without restriction.
Hours & Format
Fall and/or spring: 15 weeks - 1-4 hours of directed group study per week
Additional Details
Subject/Course Level: Molecular and Cell Biology/Undergraduate
Grading/Final exam status: Offered for pass/not pass grade only. Final exam not required.
Terms offered: Spring 2024, Spring 2023, Spring 2022
This course surveys cellular metabolism with a focus on the underlying bioenergetics, mechanisms, and chemistry. Lectures will cover major principles in the biochemistry of metabolism and also highlight selected topics including signaling, transport, metabolic engineering, and human diseases related to metabolic dysfunction. The course is designed for majors in the biochemistry and molecular biology, genetics and development, or immunology emphases. Biochemistry: Pathways, Mechanisms, and Regulation: Read More [+]
Rules & Requirements
Prerequisites: C100A/Chemistry C130
Hours & Format
Fall and/or spring: 15 weeks - 3 hours of lecture and 1 hour of discussion per week
Additional Details
Subject/Course Level: Molecular and Cell Biology/Undergraduate
Grading/Final exam status: Letter grade. Final exam required.
Terms offered: Fall 2024, Spring 2024, Fall 2023
Thermodynamic and kinetic concepts applied to understanding the chemistry and structure of biomolecules (proteins, DNA, and RNA). Molecular distributions, reaction kinetics, enzyme kinetics. Bioenergetics, energy transduction, and motor proteins. Electrochemical potential, membranes, and ion channels. Biophysical Chemistry: Physical Principles and the Molecules of Life: Read More [+]
Rules & Requirements
Prerequisites: Chemistry 3A or 112A, Mathematics 1A, Biology 1A and 1AL; Chemistry 3B or 112B recommended
Hours & Format
Fall and/or spring: 15 weeks - 3 hours of lecture and 1 hour of discussion per week
Summer: 8 weeks - 5.5 hours of lecture and 2 hours of discussion per week
Additional Details
Subject/Course Level: Molecular and Cell Biology/Undergraduate
Grading/Final exam status: Letter grade. Final exam required.
Terms offered: Fall 2024, Summer 2024 8 Week Session, Spring 2024
A comprehensive survey of the fundamentals of biological chemistry, including the properties of intermediary metabolites, the structure and function of biological macromolecules, the logic of metabolic pathways (both degradative and biosynthetic) and the molecular basis of genetics and gene expression. Survey of the Principles of Biochemistry and Molecular Biology: Read More [+]
Rules & Requirements
Prerequisites:BIOLOGY 1A and CHEM 3B with minimum grades of C- (or equivalent courses). Recommended: a course in physical chemistry
Credit Restrictions: Students will receive no credit for 102 after taking 100B or C100A/Chemistry C130 or Chemistry 135.
Hours & Format
Fall and/or spring: 15 weeks - 3 hours of lecture and 1 hour of discussion per week
Summer: 8 weeks - 6 hours of lecture and 2 hours of discussion per week 10 weeks - 4 hours of lecture and 2 hours of discussion per week
Additional Details
Subject/Course Level: Molecular and Cell Biology/Undergraduate
Grading/Final exam status: Letter grade. Final exam required.
Terms offered: Spring 2024, Spring 2023, Spring 2022
This course for upper division and graduate students will explore the molecular and cellular basis of microbial pathogenesis. The course will focus on model microbial systems which illustrate mechanisms of pathogenesis. Most of the emphasis will be on bacterial pathogens of mammals, but there will be some discussion of viral and protozoan pathogens. There will be an emphasis on experimental approaches. The course will also include some aspects of bacterial genetics and physiology, immune response to infection, and the cell biology of host-parasite interactions. Bacterial Pathogenesis: Read More [+]
Terms offered: Fall 2024, Summer 2024 8 Week Session, Spring 2024
This course will introduce students to key concepts in genetic analysis, eukaryotic cell biology, and state-of-the-art approaches in genomic medicine. Lectures will highlight basic knowledge of cellular processes with the basis for human diseases, particularly cancer. Prerequisite courses will have introduced students to the concepts of cells, the central dogma of molecular biology, and gene regulation. Emphasis in this course will be on eukaryotic cell processes, including cellular organization, dynamics, and signaling. Genetics, Genomics, and Cell Biology: Read More [+]
Terms offered: Fall 2024, Spring 2024, Fall 2023
Molecular biology of prokaryotic and eukaryotic cells and their viruses. Mechanisms of DNA replication, transcription, translation. Structure of genes and chromosomes. Regulation of gene expression. Biochemical processes and principles in membrane structure and function, intracellular trafficking and subcellular compartmentation, cytoskeletal architecture, nucleocytoplasmic transport, signal transduction mechanisms, and cell cycle control. Molecular Biology: Macromolecular Synthesis and Cellular Function: Read More [+]
Rules & Requirements
Prerequisites: C100A (may not be taken concurrently); Plan 1 Emphasis 1 (BMB) majors should take 100B prior to 110
Hours & Format
Fall and/or spring: 15 weeks - 3 hours of lecture and 1 hour of discussion per week
Additional Details
Subject/Course Level: Molecular and Cell Biology/Undergraduate
Grading/Final exam status: Letter grade. Final exam required.
Terms offered: Fall 2024, Summer 2024 10 Week Session, Fall 2023
This course will explore the molecular bases for physiological and biochemical diversity among members of the two major domains, Bacteria and Archaea. The ecological significance and evolutionary origins of this diversity will be discussed. Molecular, genetic, and structure-function analyses of microbial cell cycles, adaptive responses, metabolic capability, and macromolecular syntheses will be emphasized. General Microbiology: Read More [+]
Rules & Requirements
Prerequisites: Biology 1A and 1B
Hours & Format
Fall and/or spring: 15 weeks - 3 hours of lecture and 1 hour of discussion per week
Summer: 10 weeks - 5 hours of lecture and 1.5 hours of discussion per week
Additional Details
Subject/Course Level: Molecular and Cell Biology/Undergraduate
Grading/Final exam status: Letter grade. Final exam required.
Terms offered: Fall 2024, Spring 2024, Fall 2023
Students will become proficient in basic
microbiology research methods and
experimental design. The course covers
fundamental principles and techniques of the
microbiology lab including sterile technique,
culturing, and microscopy. Students will
learn these methods in the context of two
structured, discovery-based research projects:
predicting and analyzing the phenotypes of E.
coli metabolic mutants, and isolating and
characterizing bacteria with novel properties
from environmental samples. Student will
synthesize their results in the format of a
Journal of Bacteriology research article and a
scientific poster presentation. General Microbiology Laboratory: Read More [+]
Rules & Requirements
Prerequisites: C112 (may be taken concurrently)
Hours & Format
Fall and/or spring: 15 weeks - 4 hours of laboratory and 1 hour of discussion per week
Summer: 10 weeks - 6 hours of laboratory and 2 hours of discussion per week
Additional Details
Subject/Course Level: Molecular and Cell Biology/Undergraduate
Grading/Final exam status: Letter grade. Alternative to final exam.
Terms offered: Spring 2024, Spring 2023, Spring 2022
This course will provide a comparative overview of virus life cycles and strategies viruses use to infect and replicate in hosts. We will discuss virus structure and classification and the molecular basis of viral reproduction, evolution, assembly, and virus-host interactions. Common features used during virus replication and host cellular responses to infection will be covered. Topics also included are common and emerging virus diseases, their control, and factors affecting their spread. Introduction to Comparative Virology: Read More [+]
Rules & Requirements
Prerequisites: Introductory chemistry (Chemistry 1A or 3A-3B or equivalent) and introductory biology (Biology 1A, 1AL, and 1B or equivalent) and general biochemistry (Molecular and Cell Biology C100A or equivalent--preferably completed but may be taken concurrently)
Hours & Format
Fall and/or spring: 15 weeks - 3 hours of lecture and 1.5 hours of discussion per week
Additional Details
Subject/Course Level: Molecular and Cell Biology/Undergraduate
Grading/Final exam status: Letter grade. Final exam required.
Terms offered: Fall 2024, Fall 2022, Fall 2021
This course for upper-division and graduate students will broadly survey myriad types of microbial organisms, both procaryote and eucaryote, using a phylogenetic framework to organize the concept of "biodiversity." Emphasis will be on the evolutionary development of the many biochemical themes, how they mold our biosphere, and the organisms that affect the global biochemistry. Molecular mechanisms that occur in different lineages will be compared and contrasted to illustrate fundamental biological strategies. Graduate students additionally should enroll in C216, Microbial Diversity Workshop. Microbial Diversity: Read More [+]
Rules & Requirements
Prerequisites: Upper-division standing. C112 or consent of instructor and organic chemistry (may be taken concurrently)
Hours & Format
Fall and/or spring: 15 weeks - 3 hours of lecture and 1 hour of discussion per week
Additional Details
Subject/Course Level: Molecular and Cell Biology/Undergraduate
Grading/Final exam status: Letter grade. Final exam required.
Terms offered: Spring 2024, Spring 2023
Students will build on the central metabolic pathways to learn about plant-specific metabolism from a more mechanistic perspective, including photosynthesis, regulation of sugar and starch metabolism, chloroplast-based pathways of inorganic nutrient (nitrogen, sulfur) processing, N2 fixing in free-living and symbiotic bacteria, polyunsaturated fatty acid and oil biosynthesis and accumulation, secondary metabolism, cell-wall structure and biosynthesis. Instruction will focus on a research-based approach, including retrieving and researching the primary literature, and understanding experimental design in modern plant biochemistry. Advanced Plant Biochemistry: Read More [+]
Terms offered: Fall 2024, Fall 2023
This class is designed to introduce students to crucial concepts that underlie the discovery and development of therapeutic modalities. It will cover questions of target discovery and validation; basic properties of therapeutic modalities, such as small molecules, designer proteins, or genome engineering approaches; the design and execution of chemical screens; the medicinal chemistry, pharmacodynamics and -kinetics that is required for drug development; and the steps needed to introduce a new modality into the clinic. Lectures are based on a combination of textbook readings and primary literature and summarized through case studies that highlight critical aspects of drug discovery and development. Therapeutics Discovery and Development: Read More [+]
Terms offered: Not yet offered
This lab course will familiarize students with general principles of drug discovery and action. The first module focuses on aspects of small molecule function by comparing stoichiometric inhibitors and PROTAC molecules against the BTK kinase. Students will learn how to purify protein, monitor drug binding and in vitro efficiency, and determine effects on cell survival. The second module focuses on genomic therapies by introducing students to principles of CRISPR genome editing. Students will design genome editing strategies and cognate guide RNAs and then perform an editing experiment that replaces a catalytic Cys residue in BTK with Ser. Students will compare stoichiometric inhibitors against BTK to PROTAC in wildtype or mutant cells. Therapeutics Discovery Laboratory: Read More [+]
Terms offered: Spring 2024
This course will investigate a wide range of topics in cell biology, focusing on modern and classic experimental approaches that have provided important insights, and the relevance of their findings to understanding human health and disease. We will emphasize the importance of quantitative understanding in research topics that are current areas of discovery. We aim to convey an understanding of how cellular structure and function arise as a result of the properties of macromolecules and how understanding the behavior of molecules is needed to explain how cells and organisms operate. This understanding thus also explains what happens when normal cellular functions are impacted, leading to cellular dysfunction and disease. Cell Biology: from Discovery to Disease: Read More [+]
Terms offered: Fall 2024, Fall 2023, Fall 2022
The course is designed for students interested in learning about the molecular and cell biology of cancer and how this knowledge is being applied to the prevention, diagnosis and therapy of cancer. Topics covered include tumor pathology and epidemiology; tumor viruses and oncogenes; intracellular signaling; tumor suppressors; multi-step carcinogenesis and tumor progression; genetic instability in cancer; tumor-host interactions; invasion and metastasis; tumor immunology; cancer therapy. Biology of Human Cancer: Read More [+]
Terms offered: Fall 2024, Spring 2024, Fall 2023
Experimental analyses of central problems in cell biology and physiology using modern techniques, including DNA cloning and protein biochemistry, fluorescence microscopy of the cytoskeleton and organelles, DNA transfection and cell cycle analysis of cultured mammalian cells, RNA interference and drug treatments to analyze ion channel function in cell contractility and intracellular signaling, and somatosensation. Physiology and Cell Biology Laboratory: Read More [+]
Terms offered: Spring 2024, Fall 2022, Spring 2022
This course focuses on the structure, functions, and dynamics of eukaryotic chromosomes and their organization within cell nuclei. All life on earth relies on genetic information, which is encoded within nucleic acids (DNA and RNA). Most organisms have DNA-based genomes; bacterial and archaeal genomes typically comprise a single circular DNA molecule, while the genomes of most eukaryotes are divided into a variable number of linear DNA molecules. These contiguous DNA strands, along with the associated proteins and other components that contribute to their organization and function, are known as “chromosomes.” Genome Organization and Nuclear Dynamics: Read More [+]
Hours & Format
Fall and/or spring: 15 weeks - 2 hours of lecture and 1 hour of discussion per week
Additional Details
Subject/Course Level: Molecular and Cell Biology/Undergraduate
Grading/Final exam status: Letter grade. Final exam required.
Terms offered: Fall 2024, Fall 2023, Fall 2022
Molecular mechanisms by which hormones elicit specific responses and regulate gene expression; hormone-receptor interaction; synthesis, transport and targeting of hormones, growth factors and receptors. Topics in Cell and Developmental Biology: Molecular Endocrinology: Read More [+]
Terms offered: Fall 2024, Spring 2024, Fall 2023
Principles of mammalian (primarily human) physiology emphasizing physical, chemical, molecular and cellular bases of functional biology. The following topics will be covered: cellular and membrane ion and nonelectrolyte transport; cell and endocrine regulation; autonomic nervous system regulation; skeletal, smooth and cardiac muscle; cardiovascular physiology; respiration; renal physiology; gastrointestinal physiology. Discussion section led by Graduate Student Instructor will review material covered in lecture. Physiology: Read More [+]
Terms offered: Spring 2024, Spring 2022, Spring 2020
Biology is being revolutionized by new experimental techniques that have made it possible to measure the inner workings of molecules, cells and multicellular organisms with unprecedented precision. The objective of this course is to explore this deluge of quantitative data through the use of biological numeracy. We will develop theoretical models that make precise predictions about biological phenomena. These predictions will be tested through the hands-on analysis of experimental data and by performing numerical simulations using Matlab. A laptop is required for this course, but no previous programming experience is required. Physical Biology of the Cell: Read More [+]
Hours & Format
Fall and/or spring: 15 weeks - 3 hours of lecture and 1 hour of laboratory per week
Summer: 8 weeks - 6 hours of lecture and 2 hours of laboratory per week
Additional Details
Subject/Course Level: Molecular and Cell Biology/Undergraduate
Grading/Final exam status: Letter grade. Alternative to final exam.
Terms offered: Fall 2024, Spring 2024, Fall 2023
An in depth introduction to genes, their sexual and asexual transmission in individuals and populations, and gene regulation in prokaryotes and eukaryotes. Gene manipulation by recombination, molecular cloning and genome editing is presented in contexts ranging from fundamental mechanisms of chromosome biology to applications in development, aging and disease. Human genetic variation and quantitative evaluation are illuminated. Non-Mendelian and epigenetic modes of inheritance of transposable elements, prions and chromatin states are paired with discussions of groundbreaking technology rewriting the rules of how the genome is analyzed, with attention to the ethical considerations ranging from the history of eugenics to modern controversies. General Genetics: Read More [+]
Rules & Requirements
Prerequisites: Biology 1A and 1AL
Hours & Format
Fall and/or spring: 15 weeks - 3 hours of lecture and 1 hour of discussion per week
Additional Details
Subject/Course Level: Molecular and Cell Biology/Undergraduate
Grading/Final exam status: Letter grade. Final exam required.
Terms offered: Spring 2024, Spring 2023, Spring 2022
An introduction to principles and processes of embryonic and post-embryonic development, stressing mechanisms of cell and tissue interactions, morphogenesis and regulation of gene expression. Developmental Biology: Read More [+]
Rules & Requirements
Prerequisites: 102 or C100A; Biology 1A, 1AL, and 1B; 110 or 130 recommended
Hours & Format
Fall and/or spring: 15 weeks - 3 hours of lecture and 1 hour of discussion per week
Additional Details
Subject/Course Level: Molecular and Cell Biology/Undergraduate
Grading/Final exam status: Letter grade. Final exam required.
Terms offered: Fall 2023, Fall 2016, Fall 2015
This course is intended for upper-division undergraduates seeking an interactive course based on modern concepts in evolution and comparative genomics. The course will emphasize the contribution of molecular evolution to a series of seminal events in life's history: origin of life; origin of cells; origin of eukaryotes; origin of multicellularity; evolution of animal development; human origins. Evolution of Genomes, Cells, and Development: Read More [+]
Rules & Requirements
Prerequisites: Biology 1A-1B and Molecular and Cell Biology C100A or 102; 104 or 140 recommended
Credit Restrictions: Student will receive no credit for 143 after taking Integrative Biology 163.
Hours & Format
Fall and/or spring: 15 weeks - 3 hours of lecture and 1 hour of discussion per week
Additional Details
Subject/Course Level: Molecular and Cell Biology/Undergraduate
Grading/Final exam status: Letter grade. Final exam not required.
Terms offered: Fall 2024, Fall 2023
An analysis of the patterns and processes of organic evolution. History and philosophy of evolutionary thought; the different lines of evidence and fields of inquiry that bear on the understanding of evolution. The major features and processes of evolution through geologic times; the generation of new forms and new lineages; extinction; population processes of selection, adaptation, and other forces; genetics, genomics, and the molecular basis of evolution; evolutionary developmental biology; sexual selection; behavorial evolution; applications of evolutionary biology to medical, agricultural, conservational, and anthropological research. Evolution: Read More [+]
Rules & Requirements
Credit Restrictions: Students will receive no credit for INTEGBI 160 after completing ZOOLOGY 109.
Hours & Format
Fall and/or spring: 15 weeks - 3 hours of lecture and 1 hour of discussion per week
Additional Details
Subject/Course Level: Molecular and Cell Biology/Undergraduate
Grading/Final exam status: Letter grade. Final exam required.
Terms offered: Spring 2024, Fall 2022, Spring 2007, Spring 2005
Biology has become a data science! This lab course aims for student curiosity to drive hands-on
case studies and coding projects about biological applications of data science. The course design
supports students’ development of fundamental and transferable computational and statistical
skills for critically thinking about and using data in biology. Ethical considerations are
interwoven throughout. This course offers projects with multiple levels of sophistication and
complexity, enabling participation for students with varying levels of experience. Data Science for Biology: Read More [+]
Objectives & Outcomes
Course Objectives: Students will become empowered to use basic coding approaches to access, work with, and
analyze biological data Students will learn how to appropriately apply statistical tests to biological data Students will learn how to select and evaluate methods and tools for data analysis Students will understand how to grapple with the ethical considerations of biological data
Rules & Requirements
Prerequisites: Biology 1A; Biology 1B (can be taken concurrently); Data C8 or equivalent statistics and programming experience
Hours & Format
Fall and/or spring: 15 weeks - 4 hours of laboratory per week
Additional Details
Subject/Course Level: Molecular and Cell Biology/Undergraduate
Grading/Final exam status: Letter grade. Alternate method of final assessment during regularly scheduled final exam group (e.g., presentation, final project, etc.).
Terms offered: Spring 2024, Spring 2023, Spring 2022
Course emphasizes bacterial and archaeal genetics and comparative genomics. Genetics and genomic methods used to dissect metabolic and development processes in bacteria, archaea, and selected microbial eukaryotes. Genetic mechanisms integrated with genomic information to address integration and diversity of microbial processes. Introduction to the use of computational tools for a comparative analysis of microbial genomes and determining relationships among bacteria, archaea, and microbial eukaryotes. Microbial Genomics and Genetics: Read More [+]
Rules & Requirements
Prerequisites: Molecular and Cell Biology C100A/Chemistry C130 or Molecular and Cell Biology 102
Hours & Format
Fall and/or spring: 15 weeks - 3 hours of lecture and 1 hour of discussion per week
Summer: 8 weeks - 6 hours of lecture and 2 hours of discussion per week 10 weeks - 5 hours of lecture and 1.5 hours of discussion per week
Additional Details
Subject/Course Level: Molecular and Cell Biology/Undergraduate
Grading/Final exam status: Letter grade. Final exam required.
Terms offered: Fall 2024, Fall 2023, Fall 2022
This is an upper division course for majors in MCB with an interest in an in-depth exploration of the forces that shape the human genome and the human population, as well as the ways that human genetic information can be used in medicine, ancestry and forensics. The course will combine lectures and discussion of research papers. The Human Genome: Read More [+]
Terms offered: Fall 2024, Spring 2024, Fall 2023
Fundamentals of immunology with emphasis on biochemical and molecular approaches to study of the immune system and its application in medicine and biotechnology. Topics covered include description of the immune system, antibody and T-cell receptor structure and function, genes of the immunoglobulin superfamily, cells and molecular mediators that regulate the immune response, allergy, autoimmunity, immunodeficiency, tissue and organ transplants, and tumor immunology. Molecular Immunology: Read More [+]
Rules & Requirements
Prerequisites: C100A/Chemistry C130, or 102
Hours & Format
Fall and/or spring: 15 weeks - 3 hours of lecture and 1 hour of discussion per week
Additional Details
Subject/Course Level: Molecular and Cell Biology/Undergraduate
Grading/Final exam status: Letter grade. Final exam required.
Terms offered: Fall 2024, Spring 2024, Fall 2023
Experimental techniques in mammalian molecular biology and cellular immunology. Molecular techniques covered include PCR and recombinant DNA procedures such as gene cloning, gene transfer, DNA sequencing, Southern blot, and restriction mapping. Immunological techniques covered include cell culture and monoclonal antibody production, flow cytometry, ELISA, immunoprecipitation, and western blot. Immunology Laboratory: Read More [+]
Rules & Requirements
Prerequisites: Molecular and Cell Biology 150 (may be taken concurrently); consent of instructor
Hours & Format
Fall and/or spring: 15 weeks - 8 hours of laboratory and 1 hour of lecture per week
Additional Details
Subject/Course Level: Molecular and Cell Biology/Undergraduate
Grading/Final exam status: Letter grade. Final exam not required.
Terms offered: Fall 2024, Fall 2023, Fall 2022
The overarching goal of MCB153 is to convey to students the scientific and regulatory process by which therapeutic drugs are developed and created. After completing this course, students will have a firm understanding on the mechanism of action of several therapies used to fight disease. The course will cover areas such as the discovery and refinement of antibiotics, anti-virals, cancer therapies and CRISPR-based therapies. Furthermore, MCB153 will delve into disease areas not covered in other courses, such as autoimmune diseases, cardiovascular diseases and neurological diseases. Lastly, MCB153 will implement a “case study” for each topic displaying real world challenges and solutions to treating complex diseases. Molecular Medicine: Read More [+]
Terms offered: Fall 2023, Fall 2022, Fall 2021
Comprehensive introductory survey of cellular and molecular neuroscience, including cellular neurophysiology, ion channel function, synaptic function and plasticity, sensory transduction, and brain development. Includes introduction to molecular basis of neurological disease. Analysis from the level of molecules to cells to simple circuits. Cellular and Molecular Neurobiology: Read More [+]
Rules & Requirements
Prerequisites: Biology 1A and 1AL. Prerequisite or co-requisite: Physics 8B
Hours & Format
Fall and/or spring: 15 weeks - 3 hours of lecture and 1 hour of discussion per week
Additional Details
Subject/Course Level: Molecular and Cell Biology/Undergraduate
Grading/Final exam status: Letter grade. Final exam required.
Formerly known as: Molecular and Cell Biology C160/Neuroscience C160
Terms offered: Fall 2023, Fall 2022, Fall 2021
Experimental analyses of properties and interactions of nerve cells and systems, illustrating principal features and current methods. Techniques employed include computer simulation of neuron properties, electrophysiological recording and stimulation of nerves and cells, digitally enhanced video imaging of outgrowth, fluorescence immunocytochemistry, analysis of sensory: CNS mapping, human-evoked potential recording, sensory psychophysics. Neurobiology Laboratory: Read More [+]
Rules & Requirements
Prerequisites: Biology 1A, 1AL; Physics 8A, 8B; MCB 160 or equivalent (may be taken concurrently). Recommended: a course in physical chemistry
Hours & Format
Fall and/or spring: 15 weeks - 1 hour of lecture and 8 hours of laboratory per week
Additional Details
Subject/Course Level: Molecular and Cell Biology/Undergraduate
Grading/Final exam status: Letter grade. Final exam not required.
Terms offered: Fall 2023, Fall 2022, Fall 2021
Electrochemistry and ion transport phenomena, equivalent circuits, excitability, action potentials, voltage clamp and the Hodgkin-Huxley model. Biophysical properties of ion channels. Statistical and electrophysiological models of synaptic transmission, Quantitative models for dendritic structure and neuronal morphogenesis. Sensory transduction, cellular networks as computational devices, information processing and transfer. Biophysical Neurobiology: Read More [+]
Objectives & Outcomes
Course Objectives: 1)
Derive equations for Nernst and GHK membrane potential from fundamental physics concepts.
2)
Describe the experiments and theory underlying the Hodgkin-Huxley model.
3)
Understand biophysical properties of gating particles called ion channels.
4)
Apply and solve equivalent circuit models to describe resting and excitable cells, synaptic transmission and sensory transduction.
5)
Use Poisson, Gaussian and binomial distributions to analyze the gating of ion channels, synaptic transmission, and absolute sensitivity of vision.
6)
Model dendritic structure based on quantitative descriptors of shape and energy minimization theory.
7)
Explain experiments and models of sensory transduction, neuronal integration and lateral inhibition.
Rules & Requirements
Prerequisites: Biology 1A, 1AL, Physics 8A-8B, Chemistry 1A, 3A/3AL-3B, or consent of instructor
Hours & Format
Fall and/or spring: 15 weeks - 3 hours of lecture and 1 hour of discussion per week
Additional Details
Subject/Course Level: Molecular and Cell Biology/Undergraduate
Grading/Final exam status: Letter grade. Final exam required.
Terms offered: Fall 1995
Sensory cells monitor the environment to trigger behaviors required to feed, avoid danger and thrive. This interactive course combines lectures with instructor-led discussions of research from the scientific literature. Our goals are two fold. First, we will present current concepts in sensory neurobiology by illustrating how different sensory inputs govern homeostasis and behavior. Second, though discussions of scientific data, the course will foster critical thinking skills, and provide practice in drawing logical, evidence-based conclusions. Sensory Neuroscience: Read More [+]
Terms offered: Summer 2024 First 6 Week Session, Summer 2023 First 6 Week Session, Summer 2022 First 6 Week Session
This laboratory course for majors in Chemical Biology, Cell Biology, and Biochemistry & Molecular Biology is designed to have students learn the theory and practicality of modern laboratory science. The first and last third of the course will focus on Molecular Biology and Biochemistry where the students will learn basic skills and investigate the role of Kinesin 5 in Mitosis. In the middle Cell Biology portion of the course you will learn about cell structure and the cytoskeleton with an emphasis on microscopy techniques. Molecular and Cell Biology Laboratory: Read More [+]
Credit Restrictions: Students will receive no credit for Molecular and Cell Biology 170L after taking Molecular and Cell Biology 133L, 140L or C110L/Chemistry C110L
Hours & Format
Summer: 6 weeks - 5 hours of lecture and 14 hours of laboratory per week
Additional Details
Subject/Course Level: Molecular and Cell Biology/Undergraduate
Grading/Final exam status: Letter grade. Final exam not required.
Terms offered: Prior to 2007
Blended lecture / Project-based course where student teams build out a business plan for a mock biotech company, demonstrating advanced knowledge in therapeutics and business development. Throughout the course student teams will work toward a final project in which they will identify and present a technology overview, disease overview and explanation of unmet need, a development plan, a commercialization plan, risk mitigation strategy, and financials. Class will include field trips, guest lectures, and a pitch competition with prize. Life Sciences, Business, and Entrepreneurship Capstone Course: Read More [+]
Rules & Requirements
Prerequisites: Students must be in their fourth and final year of the Life Sciences, Business, and Entrepreneurship Program in order to enroll in this class
Hours & Format
Fall and/or spring: 15 weeks - 4 hours of lecture per week
Additional Details
Subject/Course Level: Molecular and Cell Biology/Undergraduate
Grading/Final exam status: Letter grade. Alternative to final exam.
Terms offered: Summer 2022 8 Week Session, Spring 2012, Spring 2007
Course consists of a weekly three-hour training session that focuses on laboratory techniques, instructional aids, and problem solving, plus an additional three hour weekly laboratory where the UGSI is required to assist a GSI in the instruction of laboratory (answering questions, providing demonstrations, etc.). Undergraduate Teaching of Biology 1A Laboratory: Read More [+]
Rules & Requirements
Prerequisites: Biology 1A, 1AL with a minimum grade of B. Appointment as a UGSI in biology by consent of instructor. Restricted to undergraduate students
Repeat rules: Course may be repeated for credit up to a total of 4 units.
Hours & Format
Fall and/or spring: 15 weeks - 3-6 hours of session per week
Summer: 8 weeks - 6-12 hours of session per week
Additional Details
Subject/Course Level: Molecular and Cell Biology/Undergraduate
Grading/Final exam status: Offered for pass/not pass grade only. Final exam not required.
Terms offered: Fall 2012, Fall 2011, Fall 2010
Course consists of a weekly three-hour training session that focuses on laboratory techniques, instructional aids, and problem solving, plus an additional three-hour weekly laboratory where the UGSI is required to assist a GSI in the instruction of laboratory (answering questions, providing demonstrations, etc.). Students will be graded on lecture and laboratory attendance and preparation of one quiz. Undergraduate Teaching of Molecular and Cell Biology 32 Laboratory: Read More [+]
Rules & Requirements
Prerequisites: 32, 136, or Integrative Biology 132 and Molecular and Cell Biology 32L or Integrative Biology 132L laboratory courses in physiology with minimum grades of B. Appointment as a UGSI in physiology by consent of instructor
Repeat rules: Course may be repeated for credit up to a total of 4 units.
Hours & Format
Fall and/or spring: 15 weeks - 3-6 hours of session per week
Summer: 6 weeks - 7.5-15 hours of session per week 8 weeks - 5.5-11 hours of session per week
Additional Details
Subject/Course Level: Molecular and Cell Biology/Undergraduate
Grading/Final exam status: Offered for pass/not pass grade only. Final exam required.
Terms offered: Summer 2024 3 Week Session, Summer 2023 3 Week Session, Summer 2022 3 Week Session
This 3 week course will address topics in genome editing and CRISPR-Cas9 research, including basic and enhanced CRISPR methods, cellular repair mechanisms, regulation of gene expression, bioinformatics, applications to various organisms, and bioethics. Students will learn from a collection of local experts about ongoing campus research, and gain the background knowledge to understand current publications and applications of genome editing. Intro to CRISPR: From Basic Biology to Genome Editing Technology: Read More [+]
Terms offered: Summer 2019 3 Week Session
This 3 week lab course will focus on applications of CRISPR technology as a platform for genome editing and functional genomics. The program will consist of a hands-on laboratory experience demonstrating how CRISPR systems work in situ, as well as use genome editing both in vitro and in vivo. Students will utilize fundamental molecular biology techniques and learn additional protocols specific to genome editing. Two bioinformatics based lessons will cover the essential programs and analyses used in the genome editing field. This course requires concurrent enrollment in a lecture component (MCELLBI N184), where lecturers will address topics in genome editing and CRISPR-Cas9 research. Intro to CRISPR Lab: From Basic Biology to Genome Editing Technology: Read More [+]
Rules & Requirements
Prerequisites: Biology 1A/1AL or equivalent course. MCELLBI N184 (may be taken concurrently)
Hours & Format
Summer: 3 weeks - 14 hours of laboratory per week
Additional Details
Subject/Course Level: Molecular and Cell Biology/Undergraduate
Grading/Final exam status: Offered for pass/not pass grade only. Final exam not required.
Terms offered: Spring 2021, Spring 2020
This course is intended for advanced undergraduates wishing to pursue independent research projects under the mentorship of an Molecular and Cell Biology faculty member. To apply for MCELLBI 191, the research project must be rigorous and provide significant training in biology. Senior Research Thesis: Read More [+]
Rules & Requirements
Prerequisites: Consent of instructor and departmental adviser
Fall and/or spring: 15 weeks - 9 hours of independent study per week
Summer: 6 weeks - 23 hours of independent study per week 8 weeks - 17 hours of independent study per week 10 weeks - 14 hours of independent study per week 12 weeks - 12 hours of independent study per week
Additional Details
Subject/Course Level: Molecular and Cell Biology/Undergraduate
Grading/Final exam status: Letter grade. Alternative to final exam.
Terms offered: Fall 2018, Fall 2017
UGSIs will work under supervision of instructor and/or GSI. The UGSI will attend three hours of lecture per week where they will assist a GSI in instruction (answering questions, providing demonstrations, facilitating activities, etc.). In addition, UGSIs will meet with students from their section for zero to three hours of tutoring per week depending on the number of units. UGSIs do not evaluate students' work or assign grades. UGSIs will be graded on attendance and preparation of one lesson plan and one quiz. Required to attend any mandatory preparatory and review meetings. Undergraduate Student Instructor for Molecular and Cell Biology Courses: Read More [+]
Rules & Requirements
Prerequisites: Must have completed course applying to UGSI with a grade of B or better; or consent of instructor
Repeat rules: Course may be repeated for credit up to a total of 4 units.
Hours & Format
Fall and/or spring: 15 weeks - 3-3 hours of lecture per week
Summer: 8 weeks - 6-6 hours of lecture per week
Additional Details
Subject/Course Level: Molecular and Cell Biology/Undergraduate
Grading/Final exam status: Offered for pass/not pass grade only. Alternative to final exam.
Terms offered: Fall 2015, Fall 2014, Spring 2014
Individual research and thesis preparation under the supervision of a faculty member. Acceptance to the Molecular and Cell Biology Honors Program is required. Contact the MCB Undergraduate Affairs Office, 3060 Valley Life Sciences Building, for application and details. Honor students must complete at least two semesters of research, taking a minimum of 4 units and a maximum of 8 units of H196A-196B. If desired, one semester of 199 can be used to replace H196A. Honors Research: Read More [+]
Rules & Requirements
Prerequisites: Senior honors status and consent of instructor
Repeat rules: Course may be repeated for credit up to a total of 4 units.
Hours & Format
Fall and/or spring: 15 weeks - 1-4 hours of independent study per week
Summer: 8 weeks - 1.5-7.5 hours of independent study per week
Additional Details
Subject/Course Level: Molecular and Cell Biology/Undergraduate
Grading/Final exam status: Offered for pass/not pass grade only. Final exam not required.
Terms offered: Spring 2020, Spring 2016, Spring 2015
Individual research and completion of thesis under the supervision of a faculty member. This course satisfies the thesis requirement for the Molecular and Cell Biology Department Honors Program. Contact the MCB Undergraduate Affairs Office, 3060 Valley Life Sciences Building, for program details and an application. Honor students must complete at least two semesters of research, taking a minimum of 4 units and a maximum of 8 units of H196A-196B. One semester of H196B is required. Honors Research: Read More [+]
Rules & Requirements
Prerequisites: Senior honors status and consent of instructor
Repeat rules: Course may be repeated for credit up to a total of 4 units.
Hours & Format
Fall and/or spring: 15 weeks - 1-4 hours of independent study per week
Summer: 8 weeks - 1.5-7.5 hours of independent study per week
Additional Details
Subject/Course Level: Molecular and Cell Biology/Undergraduate
Grading/Final exam status: Letter grade. Final exam not required.
Terms offered: Fall 2016
Supervised experience relevant to specific topics of biology in off-campus organizations. Written report and evaluation from internship supervisor required. Supervised Internship: Read More [+]
Rules & Requirements
Prerequisites: Consent of MCB Faculty, restricted to MCB majors and prospective majors only. Certification from supervisor that credit is required
Repeat rules: Course may be repeated for credit with instructor consent.
Hours & Format
Fall and/or spring: 15 weeks - 3 hours of internship per week
Summer: 6 weeks - 8 hours of internship per week
Additional Details
Subject/Course Level: Molecular and Cell Biology/Undergraduate
Grading/Final exam status: Offered for pass/not pass grade only. Final exam not required.
Terms offered: Spring 2024, Fall 2023, Spring 2023
Lectures and small group discussions focusing on topics of interest, varying from semester to semester. Directed Group Study: Read More [+]
Rules & Requirements
Prerequisites: Upper division standing
Repeat rules: Course may be repeated for credit without restriction.
Hours & Format
Fall and/or spring: 15 weeks - 1-4 hours of directed group study per week
Additional Details
Subject/Course Level: Molecular and Cell Biology/Undergraduate
Grading/Final exam status: Offered for pass/not pass grade only. Final exam not required.
Repeat rules: Course may be repeated for credit without restriction.
Hours & Format
Fall and/or spring: 15 weeks - 1-4 hours of independent study per week
Summer: 6 weeks - 1-4 hours of independent study per week 8 weeks - 1-4 hours of independent study per week 10 weeks - 1-4 hours of independent study per week 12 weeks - 1-4 hours of independent study per week
Additional Details
Subject/Course Level: Molecular and Cell Biology/Undergraduate
Grading/Final exam status: Offered for pass/not pass grade only. Final exam not required.
Terms offered: Fall 2024, Fall 2023, Fall 2022
The goal of this course is to provide graduate-level instruction on molecular and cellular biosciences from a highly-integrated systems perspective, rather than using a more classic, techniques-oriented format. A collection of approaches, and a focus on critical thinking and problem solving, will be used to show how fundamental, highly-significant biological problems are "cracked open." Reading will be assigned from a mix of classic and current peer-reviewed papers selected by the instructors. Fundamentals of Molecular and Cell Biology: Read More [+]
Rules & Requirements
Prerequisites: 200A and 200B must be taken concurrently. Combined course required and restricted to all MCB first-year graduate students
Hours & Format
Fall and/or spring: 15 weeks - 2 hours of lecture and 4 hours of discussion per week
Additional Details
Subject/Course Level: Molecular and Cell Biology/Graduate
Grading: Offered for satisfactory/unsatisfactory grade only.
Terms offered: Fall 2024, Fall 2023, Fall 2022
The goal of this course is to provide graduate-level instruction on molecular and cellular biosciences from a highly-integrated systems perspective, rather than using a more classic, techniques-oriented format. A collection of approaches, and a focus on critical thinking and problem solving, will be used to show how fundamental, highly-significant biological problems are "cracked open." Reading will be assigned from a mix of classic and current peer-reviewed papers selected by the instructors. Fundamentals of Molecular and Cell Biology: Read More [+]
Rules & Requirements
Prerequisites: Must be taken concurrently. Combined course required for all MCB first-year graduate students
Hours & Format
Fall and/or spring: 15 weeks - 6 hours of lecture per week
Additional Details
Subject/Course Level: Molecular and Cell Biology/Graduate
Grading: Offered for satisfactory/unsatisfactory grade only.
Terms offered: Summer 2024 Second 6 Week Session
This course seeks to develop students’ foundation in critical lab skills and introduce them to the fundamental principles and technologies driving modern biomedical research. After completing MCELLBI 201A, students will have a firm understanding of CRISPR gene editing, cell culture, and genomic analysis. Students will learn the fundamentals of hypothesis-driven research, obtain critical thinking skills for data interpretation, and deliver effective written and oral reports of their results. CRISPR Gene Editing, Stem Cell and Genomic Analysis: Read More [+]
Terms offered: Fall 2024
This course seeks to build upon students’ foundations set in MCELLBI 201A, in which they were introduced to the fundamental principles and technologies driving modern biomedical research. MCELLBI 201B aims to develop students’ skills in bioinformatics and quantitative data analysis. After completing this course, students will understand the RNA-Seq and ChIP-Seq pipelines and carry out their own analyses. Students will continue to learn the fundamentals of experimental design, obtain critical thinking skills for data interpretation, and deliver effective presentations on their results. CRISPR Gene Editing, Stem Cell and Genomic Analysis: Read More [+]
Terms offered: Fall 2024, Fall 2023, Spring 2023
This course is intended for graduate students in the early stages of their thesis research who are contemplating using modern microscopy tools as part of their work. It endeavors to cut through the confusion of the wide array of new imaging methods, with a practical description of the pros and cons of each. In addition to providing an intuitive physical understanding how these microscopes work, the course will offer hands on experience with cutting-edge microscopes where students will be able to see firsthand how different imaging modalities perform on their own samples, and where they will be able to access computational tools for the visualization and analysis of their data. Modern Optical Microscopy for the Modern Biologist: Read More [+]
Rules & Requirements
Credit Restrictions: Students will receive no credit for MCELLBI 205 after completing MCELLBI 205, or MCELLBI 205. A deficient grade in MCELLBI 205 may be removed by taking MCELLBI 205, or MCELLBI 205.
Hours & Format
Fall and/or spring: 15 weeks - 3 hours of lecture per week
Additional Details
Subject/Course Level: Molecular and Cell Biology/Graduate
Terms offered: Spring 2024, Spring 2023, Spring 2022
Application of modern physical concepts and experimental methods to the analysis of the structure, function, and interaction of large molecules of biological interest. Physical Biochemistry: Read More [+]
Rules & Requirements
Prerequisites: MCB C100A or equivalent. Admission to the course requires formal consent of instructors, except for MCB and Biophysics graduate students and graduate students in the laboratories of MCB faculty
Hours & Format
Fall and/or spring: 15 weeks - 3 hours of lecture per week
Additional Details
Subject/Course Level: Molecular and Cell Biology/Graduate
Terms offered: Spring 2024, Spring 2023, Spring 2022
General course for first-year graduate students. Covers our current understanding of, methodological approaches for analyzing, and recent advances in the function of cellular macromolecules and macromolecular complexes in DNA replication, recombination, transposition and repair, gene expression and its regulation, mRNA splicing, genome organization, noncoding RNAs, signal transduction, protein synthesis, folding and degradation, growth control, and other life processes. Advanced Biochemistry and Molecular Biology: Macromolecular Reactions and the Cell: Read More [+]
Rules & Requirements
Prerequisites: 110 or equivalent. Admission to the course requires formal consent of instructors, except for MCB graduate students and graduate students in the laboratories of MCB faculty
Hours & Format
Fall and/or spring: 15 weeks - 3 hours of lecture and 1 hour of discussion per week
Additional Details
Subject/Course Level: Molecular and Cell Biology/Graduate
Terms offered: Spring 2024, Spring 2023, Spring 2022
This course will present the structure of proteins, nucleic acids, and oligosaccharides from the perspective of organic chemistry. Modern methods for the synthesis and purification of these molecules will also be presented. Chemical Biology I - Structure, Synthesis and Function of Biomolecules: Read More [+]
Hours & Format
Fall and/or spring: 5 weeks - 3 hours of lecture per week
Additional Details
Subject/Course Level: Molecular and Cell Biology/Graduate
Terms offered: Spring 2024, Spring 2023, Spring 2022
This course will focus on the principles of enzyme catalysis. The course will begin with an introduction of the general concepts of enzyme catalysis which will be followed by detailed examples that will examine the chemistry behind the reactions and the three-dimensional structures that carry out the transformations. Chemical Biology II - Enzyme Reaction Mechanisms: Read More [+]
Hours & Format
Fall and/or spring: 5 weeks - 3 hours of lecture per week
Additional Details
Subject/Course Level: Molecular and Cell Biology/Graduate
Terms offered: Spring 2024, Spring 2023, Spring 2022
This course will build on the principles discussed in Chemical Biology I and II. The focus will consist of case studies where rigorous chemical approaches have been brought to bear on biological questions. Potential subject areas will include signal transduction, photosynthesis, immunology, virology, and cancer. For each topic, the appropriate bioanalytical techniques will be emphasized. Chemical Biology III - Contemporary Topics in Chemical Biology: Read More [+]
Hours & Format
Fall and/or spring: 5 weeks - 3 hours of lecture per week
Additional Details
Subject/Course Level: Molecular and Cell Biology/Graduate
Terms offered: Spring 2020, Spring 2015, Spring 2014, Spring 2013
The topics covered will be chosen from the following: protein structure; protein-protein interactions; enzyme kinetics and mechanism; enzyme design. Intended for graduate students in chemistry, biochemistry, and molecular and cell biology. Protein Chemistry, Enzymology, and Bio-organic Chemistry: Read More [+]
Rules & Requirements
Prerequisites: Graduate standing or consent of instructor
Hours & Format
Fall and/or spring: 10 weeks - 3 hours of lecture per week 15 weeks - 2 hours of lecture per week
Additional Details
Subject/Course Level: Molecular and Cell Biology/Graduate
Terms offered: Fall 2024, Fall 2022, Fall 2021, Fall 2020
This workshop for graduate students will parallel C116, Microbial Diversity, which should be taken concurrently. Emphasis in the workshop will be on review of research literature and formulation of paper pertinent to research in microbial diversity. Microbial Diversity Workshop: Read More [+]
Rules & Requirements
Prerequisites: Graduate standing; C112 or consent of instructor and organic chemistry (may be taken concurrently)
Hours & Format
Fall and/or spring: 15 weeks - 1 hour of workshop and 1 hour of discussion per week
Additional Details
Subject/Course Level: Molecular and Cell Biology/Graduate
Grading: Letter grade.
Instructor: Coates
Formerly known as: Molecular and Cell Biology C216, Plant and Microbial Biology C216
Terms offered: Fall 2024, Spring 2024, Fall 2023
In our laboratory, we study mechanisms by which molecules are transported across lipid bilayer membranes. Current research efforts to understand mechanisms of protein translocation across intracellular organelles and transport of other biomolecules will be discussed. Research Review in Molecular Mechanisms of Membrane Transport: Read More [+]
Rules & Requirements
Prerequisites: Enrollment is restricted to students conducting research in the laboratory of the instructor, or requires consent of instructor
Repeat rules: Course may be repeated for credit without restriction.
Hours & Format
Fall and/or spring: 15 weeks - 2 hours of seminar per week
Additional Details
Subject/Course Level: Molecular and Cell Biology/Graduate
Grading: Offered for satisfactory/unsatisfactory grade only.
Terms offered: Fall 2024, Spring 2024, Fall 2023
Yildiz laboratory combines molecular biology and single molecule biophysical techniques to understand mechanisms that underlie cellular organization and motility. Specific focuses of the lab are to dissect 1) the mechanism of cytoplasmic dynein motility, 2) the regulation of intraflagellar transport, and 3) the protection and maintenance of mammalian telomeres. Research Review in Biochemistry and Molecular Biology: Single Molecular Imaging of Macromolecular Enzymes: Read More [+]
Rules & Requirements
Prerequisites: Enrollment is restricted to students conducting research in the laboratory of the instructor, or requires consent of instructor
Repeat rules: Course may be repeated for credit without restriction.
Hours & Format
Fall and/or spring: 15 weeks - 2 hours of seminar per week
Additional Details
Subject/Course Level: Molecular and Cell Biology/Graduate
Grading: Offered for satisfactory/unsatisfactory grade only.
Terms offered: Spring 2023, Fall 2022, Spring 2022
Different methods for determining how the in situ structure and arrangement of macromolecular complexes influence cell morphology and
function will be discussed via literature review and implemented through lab-based research and discussions.
Terms offered: Fall 2024, Spring 2024, Fall 2023
The mechanisms by which protein complexes use their structures to bud, bend, and sever membranes will be covered in research reports and reviews of the current literature and in discussion of current experiments in the field. Structural Membrane Biology: Read More [+]
Rules & Requirements
Prerequisites: Enrollment is restricted to students conducting research in the laboratory of the instructor, or requires consent of instructor
Repeat rules: Course may be repeated for credit without restriction.
Hours & Format
Fall and/or spring: 15 weeks - 2 hours of seminar per week
Additional Details
Subject/Course Level: Molecular and Cell Biology/Graduate
Grading: Offered for satisfactory/unsatisfactory grade only.
Terms offered: Fall 2024, Spring 2024, Fall 2023
Understanding the molecular basis and physiological role of translational regulation in gene expression with an emphasis on global profiling and functional genomics. Regulation of Translation: Read More [+]
Rules & Requirements
Prerequisites: Enrollment is restricted to students conducting research in the laboratory of the instructor, or requires consent of instructor
Repeat rules: Course may be repeated for credit without restriction.
Hours & Format
Fall and/or spring: 15 weeks - 2 hours of seminar per week
Additional Details
Subject/Course Level: Molecular and Cell Biology/Graduate
Grading: Offered for satisfactory/unsatisfactory grade only.
Terms offered: Fall 2024, Spring 2024, Fall 2023
Methods of single molecule manipulation and visualization that are used to characterize the structure and mechanochemical properties of translocating DNA binding protein such as RNA polymerase and to investigate the mechanical denaturation of single protein molecules will be covered in research reports and reviews of the current literature and in discussion of current experiments in the field. Research Review in Biochemistry and Molecular Biology: Single Molecule Biophysics: Read More [+]
Rules & Requirements
Prerequisites: Enrollment is restricted to students conducting research in the laboratory of the instructor, or requires consent of instructor
Repeat rules: Course may be repeated for credit without restriction.
Hours & Format
Fall and/or spring: 15 weeks - 2 hours of seminar per week
Additional Details
Subject/Course Level: Molecular and Cell Biology/Graduate
Grading: Offered for satisfactory/unsatisfactory grade only.
Terms offered: Spring 2024
This class is designed to introduce graduate students to a range of therapeutic modalities that are in development or use. It will focus on small molecules, genomic therapies (including genome editing), and biologics. This class will present different applications of small molecules, RNA or DNA therapeutics, and biologics and discuss both advantages and challenges in their clinical use. Therapeutic Modalities: Read More [+]
Rules & Requirements
Prerequisites: For MCB students, MCELLBI 200A and MCELLBI 200B are prerequisites for this class. Students outside of MCB should check with the head instructor whether they have the required background to follow this class most productively
Terms offered: Fall 2024
The overarching goal of this course is to provide students with professional skills in scientific reading, scientific writing, creating a CV or resume and cover letters and understanding the structures of academic institutions and biotech companies. In addition, the class will provide career advice for students entering the academic or biotech work places. Science Writing and Professional Development: Read More [+]
Rules & Requirements
Prerequisites: This course will be limited to students enrolled in the MCB Master of Biotechnology program
Hours & Format
Fall and/or spring: 15 weeks - 2 hours of lecture per week
Additional Details
Subject/Course Level: Molecular and Cell Biology/Graduate
Terms offered: Fall 2024, Spring 2024, Fall 2023
Research review in genetics, genomics and development. We will explore how the detection of single particles
(DNA, RNA, proteins) can help with understanding cellular organization and
enzymatic processes dynamics and kinetics. Most of the experiments
described will be drawn from the gene expression and nuclear organization
literature. Research Review in Molecular Therapeutics: Imaging Single Molecules: Fashion or Game Changer?: Read More [+]
Rules & Requirements
Prerequisites: Enrollment is restricted to students conducting research in the laboratory of the instructor, or requires consent of instructor
Repeat rules: Course may be repeated for credit without restriction.
Hours & Format
Fall and/or spring: 15 weeks - 2 hours of seminar per week
Additional Details
Subject/Course Level: Molecular and Cell Biology/Graduate
Grading: Offered for satisfactory/unsatisfactory grade only.
Instructor: Darzacq
Formerly known as: Molecular and Cell Biology 249L
Terms offered: Fall 2024, Spring 2024, Fall 2023
We will discuss current research in the following three areas: 1) mapping metabolic drivers of human diseases using
chemoproteomic and metabolomic platforms; 2) expanding the druggable proteome through mapping and pharmacologically interrogating proteome-wide
hyper-reactive and ligandable hotspots; 3) mapping proteome-wide targets of environmental and pharmaceutical chemicals towards understanding novel
toxicological mechanisms.
Terms offered: Fall 2024, Spring 2024, Fall 2023
Covers aspects of ribosome engineering, organelle imaging and interactions, protein delivery, and cell signaling.
Terms offered: Fall 2024, Spring 2024, Fall 2023
Research focuses on (i) understanding the interplay between regulatory information encoded in the primary sequence of the human genome and epigenomic information inscribed by the joint action of trans-acting factors, chromatin remodelers, modifiers, and readers that yields a particular functional state in primary cells of the immune and central nervous systems; (ii) leveraging this understanding to engineer novel architectures for targeted epigenome editors customized for use in these and other clinically relevant human cell types; (iii) establishing preclinical proof-of-concept for the use of the resulting epigenome-editing molecular therapeutics in ex vivo and in vivo models of autoimmune and neurologic disease. Research Review in Molecular Therapeutics: Structure and Function of the Human Epigenome: Read More [+]
Rules & Requirements
Prerequisites: Enrollment is restricted to students conducting research in the laboratory of the instructor, or requires consent of instructor
Repeat rules: Course may be repeated for credit without restriction.
Hours & Format
Fall and/or spring: 15 weeks - 2 hours of seminar per week
Additional Details
Subject/Course Level: Molecular and Cell Biology/Graduate
Grading: Offered for satisfactory/unsatisfactory grade only.
Instructor: Urnov
Formerly known as: Molecular and Cell Biology 249AA
Terms offered: Fall 2024, Spring 2024, Fall 2023
The molecular engineering of novel delivery technology to facilitate therapeutic genome editing. Delivery of pre-formed CRISPR ribonucleoprotein enzymes is a central focus, and progress in the field will be covered via research presentations as well as reviews of recent literature. Research Review in Molecular Therapeutics: CRISPR Enzyme Delivery Technology: Read More [+]
Rules & Requirements
Prerequisites: Enrollment is restricted to students conducting research in the laboratory of the instructor, or requires consent of instructor
Repeat rules: Course may be repeated for credit without restriction.
Hours & Format
Fall and/or spring: 15 weeks - 2 hours of seminar per week
Additional Details
Subject/Course Level: Molecular and Cell Biology/Graduate
Grading: Offered for satisfactory/unsatisfactory grade only.
Instructor: Wilson
Formerly known as: Molecular and Cell Biology 218G
Terms offered: Spring 2024, Spring 2023, Spring 2022
This course will discuss modern concepts of cell and developmental biology, with a strong emphasis on regulatory mechanisms at different length-scales (intermolecular, intracellular and intercellular). It will cover methods of quantitative, single-cell, and organismal biology in cell lines, stem cells, and model organisms. A solid foundation of core cell biology concepts, such as the cell cycle, cytoskeleton, or vesicle transport, is strongly recommended. Advanced Cell and Developmental Biology: Read More [+]
Rules & Requirements
Prerequisites: 130. Formal consent of instructors required, except for MCB graduate students and graduate students in the laboratories of MCB faculty
Hours & Format
Fall and/or spring: 15 weeks - 3 hours of lecture and 1 hour of discussion per week
Additional Details
Subject/Course Level: Molecular and Cell Biology/Graduate
Terms offered: Spring 2018, Spring 2017, Spring 2015
Principles of animal development will be set forth from the classical and recent experimental analysis of induction, localization, patterning mutants, axis formation, regional gene expression, and cell interactions. Early development of selected vertebrates and invertebrates will be examined, and emerging topics in microRNA and stem cell biology will be highlighted. A weekly discussion section with readings from the research literature is required. Advanced Developmental and Stem Cell Biology: Read More [+]
Rules & Requirements
Prerequisites: Previous course in development (131 or equivalent) or consent of instructor
Hours & Format
Fall and/or spring: 15 weeks - 3 hours of lecture and 1-2 hours of discussion per week
Additional Details
Subject/Course Level: Molecular and Cell Biology/Graduate
Terms offered: Fall 2024, Fall 2023, Fall 2022
Principles of mammalian (primarily human) physiology emphasizing physical, chemical, molecular, and cellular bases of functional biology. The following topics will be covered: cellular and membrane ion and nonelectrolyte transport; cell and endocrine regulation; autonomic nervous system regulation; skeletal, smooth, and cardiac muscle; cardiovascular physiology; respiration; renal physiology; gastrointestinal physiology. Discussion section will study advanced physiological topics, including: presentations by the faculty; problem sets; discussion of the primary literature and of reviews; two presentations by each student on topics in current physiological research. Advanced Mammalian Physiology: Read More [+]
Rules & Requirements
Prerequisites: Consent of instructor
Hours & Format
Fall and/or spring: 15 weeks - 3 hours of lecture and 2 hours of discussion per week
Additional Details
Subject/Course Level: Molecular and Cell Biology/Graduate
Terms offered: Spring 2024, Spring 2022, Spring 2020
Biology is being revolutionized by new experimental techniques that have made it possible to measure the inner workings of molecules, cells and multicellular organisms with unprecedented precision. The objective of this course is to explore this deluge of quantitative data through the use of biological numeracy. We will develop theoretical models that make precise predictions about biological phenomena. These predictions will be tested through the hands-on analysis of experimental data and by performing numerical simulations using Matlab. A laptop is required for this course, but no previous programming experience is required. Advanced Physical Biology of the Cell: Read More [+]
Hours & Format
Fall and/or spring: 15 weeks - 3 hours of lecture and 1 hour of laboratory per week
Summer: 8 weeks - 6 hours of lecture and 2 hours of laboratory per week
Additional Details
Subject/Course Level: Molecular and Cell Biology/Graduate
Terms offered: Spring 2015, Spring 2014, Spring 2013
This course will provide an overview of basic and applied embryonic stem cell (ESC) biology. Topics will include early embryonic development, ESC laboratory methods, biomaterials for directed differentiation and other stem cell manipulations, and clinical uses of stem cells. Stem Cells and Directed Organogenesis: Read More [+]
Rules & Requirements
Prerequisites: Consent of instructor
Hours & Format
Fall and/or spring: 15 weeks - 6 hours of laboratory and 1 hour of lecture per week
Additional Details
Subject/Course Level: Molecular and Cell Biology/Graduate
Terms offered: Fall 2023, Fall 2022
This lecture series will cover modern approaches to stem cell biology, regenerative medicine and gene therapy. Lectures will include a broad introduction to the day’s topic, followed by in depth discussion of one specific recent example- preferably from the speaker’s own laboratory-that addresses an imminent question in the field. Relevant research articles will be assigned as background reading. Students are expected to become thoroughly familiar with these materials prior to each class meeting. Stem Cell Research and Gene Therapy: Questions, Solutions and Current Frontiers: Read More [+]
Hours & Format
Fall and/or spring: 15 weeks - 1 hour of lecture and 1 hour of discussion per week
Additional Details
Subject/Course Level: Molecular and Cell Biology/Graduate
Grading: Offered for satisfactory/unsatisfactory grade only.
Terms offered: Fall 2024, Spring 2024, Fall 2023
Research in our laboratory is focused on the mechanics and dynamics of cell movements on the purified protein, single cell, and tissue levels. For these studies, we are developing new instruments to quantify cell and molecular mechanics bases on optical microscopy, force microscopy, and microfabrication. Research Review in Cell and Developmental Biology: Mechanics and Dynamics of Cell Movements: Read More [+]
Rules & Requirements
Prerequisites: Enrollment is restricted to students conducting research in the laboratory of the instructor, or requires consent of instructor
Repeat rules: Course may be repeated for credit without restriction.
Hours & Format
Fall and/or spring: 15 weeks - 2 hours of seminar per week
Additional Details
Subject/Course Level: Molecular and Cell Biology/Graduate
Grading: Offered for satisfactory/unsatisfactory grade only.
Terms offered: Fall 2024, Spring 2024, Fall 2023
The mechanisms that link cellular differentiation programs and dynamic gene regulation in complex eukaryotic systems remain mysterious. Such programs drive diverse and central biological processes including organismal development, immune function, disease progression, and meiosis. This course is focused on the molecular basis for the cellular remodeling accompanying meiosis, the highly conserved process by which gametes are produced. The Regulation of Meiotic Gene Expression and Cellular Morphogenesis: Read More [+]
Rules & Requirements
Prerequisites: Enrollment is restricted to students conducting research in the laboratory of the instructor, or requires consent of instructor
Repeat rules: Course may be repeated for credit without restriction.
Hours & Format
Fall and/or spring: 15 weeks - 2 hours of seminar per week
Additional Details
Subject/Course Level: Molecular and Cell Biology/Graduate
Grading: Offered for satisfactory/unsatisfactory grade only.
Terms offered: Fall 2024, Spring 2024, Spring 2018
Review of relevant literature and discussion of ongoing research: cytoskeletal regulation and mRNA transport in glia; organelle biogenesis and homeostasis, including of Golgi outposts; myelination in learning and behavior; gliovascular development; biophysics of liquid condensates; mechanisms of neurological disease. Research Review in Cell and Developmental Biology: Glial Cell Biology: Read More [+]
Rules & Requirements
Prerequisites: Enrollment is restricted to students conducting research in the laboratory of the instructor, or requires consent of instructor
Repeat rules: Course may be repeated for credit without restriction.
Hours & Format
Fall and/or spring: 15 weeks - 2 hours of seminar per week
Additional Details
Subject/Course Level: Molecular and Cell Biology/Graduate
Grading: Offered for satisfactory/unsatisfactory grade only.
Terms offered: Fall 2024, Spring 2024, Fall 2023
Review of relevant literature and discussion of current research: Mitochondrial dynamics, transport and inheritance; replication, segregation and distribution of mitochondrial genomes; underlying mechanisms of human mitochondrial disease. Research Review in Cell and Developmental Biology: Mitochondrial biology: Read More [+]
Rules & Requirements
Prerequisites: Enrollment is restricted to students conducting research in the laboratory of the instructor, or requires consent of instructor
Repeat rules: Course may be repeated for credit without restriction.
Hours & Format
Fall and/or spring: 15 weeks - 2 hours of seminar per week
Additional Details
Subject/Course Level: Molecular and Cell Biology/Graduate
Grading: Offered for satisfactory/unsatisfactory grade only.
Terms offered: Fall 2024, Spring 2024, Fall 2023
Review of current literature and discussion of current research. Current research focuses on regulation of energy metabolism and the effect of changes in energy metabolism induced by diet and exercise on age-associated functional decline of organisms. Research Review in Cell and Developmental Biology: Energy Metabolism and Aging: Read More [+]
Rules & Requirements
Prerequisites: Enrollment is restricted to students conducting research in the laboratory of the instructor, or requires consent of instructor
Repeat rules: Course may be repeated for credit without restriction.
Hours & Format
Fall and/or spring: 15 weeks - 2 hours of seminar per week
Additional Details
Subject/Course Level: Molecular and Cell Biology/Graduate
Grading: Offered for satisfactory/unsatisfactory grade only.
Terms offered: Fall 2024, Spring 2024, Fall 2023
The goal of our laboratory is to understand the key functions of telomeres and telomerase in tissue homeostasis, tumorigenesis, and aging. To this end, we generate genetically engineered human pluripotent and adult stem cell models to measure telomere and telomerase function during cellular differentiation and tumor formation. Research Review in Cell and Developmental Biology: Telomere Biology of Human Stem Cells: Read More [+]
Rules & Requirements
Prerequisites: Enrollment is restricted to students conducting research in the laboratory of the instructor, or requires consent of instructor
Repeat rules: Course may be repeated for credit without restriction.
Hours & Format
Fall and/or spring: 15 weeks - 2 hours of seminar per week
Additional Details
Subject/Course Level: Molecular and Cell Biology/Graduate
Grading: Offered for satisfactory/unsatisfactory grade only.
Terms offered: Fall 2023, Spring 2023, Fall 2022
Research in our lab is focused on the cell biology of mammalian fertilization. Our lab uses biophysical, biochemical, and molecular genetics methods to study sperm ion channels and transporters that regulate sperm motility, chemotaxis, and the acrosome reaction. A better understanding of these processes will eventually lead to the development of effective tools to control and preserve male fertility, improve the reproductive health of human population worldwide, and advance family planning. Research Review in Cell and Developmental Biology: The Cell Biology of Fertilization: Read More [+]
Rules & Requirements
Prerequisites: Enrollment is restricted to students conducting research in the laboratory of the instructor, or requires consent of instructor
Repeat rules: Course may be repeated for credit without restriction.
Hours & Format
Fall and/or spring: 15 weeks - 2 hours of seminar per week
Additional Details
Subject/Course Level: Molecular and Cell Biology/Graduate
Grading: Offered for satisfactory/unsatisfactory grade only.
Terms offered: Spring 2024, Spring 2023, Spring 2022
Principles and practice of classical and modern genetic analysis as applied to eukaryotic organisms, including yeast, nematodes, , mice and humans; isolation and analysis of mutations; gene mapping; suppressor analysis; chromosome structure; control of gene expression; and developmental genetics. Advanced Genetic Analysis: Read More [+]
Rules & Requirements
Prerequisites: Graduate standing with 110 or 140 or consent of instructor
Hours & Format
Fall and/or spring: 15 weeks - 3 hours of lecture and 1 hour of discussion per week
Additional Details
Subject/Course Level: Molecular and Cell Biology/Graduate
Terms offered: Fall 2024, Spring 2024, Fall 2023
This graduate seminar consists of weekly presentations from Berkeley graduate students as well as outside speakers on topics surrounding evolution, genetics, and genomics. Many labs spread across different departments have research programs focused on evolution, genetics, and genomics. However, it can be challenging to keep abreast of this research and to identify potential collaborations due to the dispersion of labs across different departments and specialties. The Center for Theoretical and Evolutionary Genetics (CTEG) is an informal group of labs that collectively work on genetics and genomics. The seminar seeks to provide a common space for graduate students to present their research and learn about the research of their colleagues. CTEG Evolution, Genetics, and Genomics Seminar: Read More [+]
Rules & Requirements
Prerequisites: Graduate standing
Repeat rules: Course may be repeated for credit without restriction.
Hours & Format
Fall and/or spring: 15 weeks - 1 hour of seminar per week
Additional Details
Subject/Course Level: Molecular and Cell Biology/Graduate
Grading: Offered for satisfactory/unsatisfactory grade only.
Terms offered: Spring 2015, Spring 2014
A graduate seminar class in which a group of students will closely examine recent computational methods in high-throughput sequencing followed by directly examining interesting biological applications thereof. Seq: Methods and Applications: Read More [+]
Rules & Requirements
Prerequisites: Graduate standing in Math, MCB, and Computational Biology; or consent of the instructor
Hours & Format
Fall and/or spring: 15 weeks - 3 hours of lecture per week
Additional Details
Subject/Course Level: Molecular and Cell Biology/Graduate
Terms offered: Spring 2013
Introduction to algebraic statistics and probability, optimization, phylogenetic combinatorics, graphs and networks, polyhedral and metric geometry. Discrete Mathematics for the Life Sciences: Read More [+]
Hours & Format
Fall and/or spring: 15 weeks - 3 hours of lecture per week
Additional Details
Subject/Course Level: Molecular and Cell Biology/Graduate
Terms offered: Fall 2024, Spring 2024, Spring 2014
This course explores experimental and computational approaches to studying the sequence to function relationships of intrinsically disordered proteins. Emphasis on the activation domains of transcription factors. High-throughput experiments, machine learning, evolutionary comparisons, and all atom simulations will be discussed. Additional emphasis will be placed on characterizing the functional consequences of patient mutations in activation domains. Research in Genetics and Development: From Sequence to Function in Transcription Factors: Read More [+]
Rules & Requirements
Prerequisites: Enrollment is restricted to students conducting research in the laboratory of the instructor, or requires consent of instructor
Repeat rules: Course may be repeated for credit without restriction.
Hours & Format
Fall and/or spring: 15 weeks - 2 hours of seminar per week
Additional Details
Subject/Course Level: Molecular and Cell Biology/Graduate
Grading: Offered for satisfactory/unsatisfactory grade only.
Terms offered: Fall 2024, Spring 2024, Fall 2023
This course focuses on understanding 1) how cellular aging is affected during gametogenesis, the developmental program that produces gametes for sexual reproduction and 2) how chromosome segregation is regulated during meiosis, the specialized cell division that generates gametes. Investigating Cellular Aging and Chromosome Segregation during Gametogenesis: Read More [+]
Rules & Requirements
Prerequisites: Enrollment is restricted to students conducting research in the laboratory of the instructor, or requires consent of instructor
Repeat rules: Course may be repeated for credit without restriction.
Hours & Format
Fall and/or spring: 15 weeks - 2 hours of seminar per week
Additional Details
Subject/Course Level: Molecular and Cell Biology/Graduate
Grading: Offered for satisfactory/unsatisfactory grade only.
Terms offered: Fall 2024, Spring 2024, Fall 2023
Research focuses on use of statistical and computational approaches to study questions in human genetics and evolutionary biology. This includes, but is not limited to, studying (1) how different evolutionary processes such as mutation rate evolve across primates, (2) when key events (such as introgression and adaptations) occurred in human history, and (3) how we can leverage large-scale datasets to identify genetic variants related to human adaptation and disease. Research Review in Genetics and Development: Human Population Genetics and Evolutionary Biology: Read More [+]
Rules & Requirements
Prerequisites: Enrollment is restricted to students conducting research in the laboratory of the instructor, or requires consent of instructor
Repeat rules: Course may be repeated for credit without restriction.
Hours & Format
Fall and/or spring: 15 weeks - 2 hours of seminar per week
Additional Details
Subject/Course Level: Molecular and Cell Biology/Graduate
Grading: Offered for satisfactory/unsatisfactory grade only.
Terms offered: Fall 2024, Spring 2024, Fall 2023
How does the sequence of an RNA determine its post-transcriptional regulation? Genomic and systems biology investigations of alternative splicing, translation, and other post-transcriptional regulatory processes. Research Review in Genetics and Development: RNA Systems Biology: Read More [+]
Rules & Requirements
Prerequisites: Enrollment is restricted to students conducting research in the laboratory of the instructor, or requires consent of instructor
Repeat rules: Course may be repeated for credit without restriction.
Hours & Format
Fall and/or spring: 15 weeks - 2 hours of seminar per week
Additional Details
Subject/Course Level: Molecular and Cell Biology/Graduate
Grading: Offered for satisfactory/unsatisfactory grade only.
Terms offered: Fall 2024, Spring 2024, Fall 2023
Research review in genetics, genomics and development. In development a single cell goes through a series of repeated divisions
and these cells read the program encoded in their DNA in order to become
familiar cell types such as those found in muscle, liver, or our brains. The
goal of our lab is to uncover the rules behind these decisions with the
objective of predicting and manipulating developmental programs from just
looking at DNA sequence. In order to reach this predictive understanding we
combine physics, synthetic biology, and new technologies to query and
control developmental decisions in real time at the single cell level in
the fruit fly embryo. Physical Biology of Living Organisms: Read More [+]
Rules & Requirements
Prerequisites: Enrollment is restricted to students conducting research in the laboratory of the instructor, or requires consent of instructor
Repeat rules: Course may be repeated for credit without restriction.
Hours & Format
Fall and/or spring: 15 weeks - 2 hours of seminar per week
Additional Details
Subject/Course Level: Molecular and Cell Biology/Graduate
Grading: Offered for satisfactory/unsatisfactory grade only.
Terms offered: Fall 2024, Spring 2024, Fall 2023
This course will focus on mechanisms of gene control in vertebrate animals, particularly in the area of vertebrate development. Amphibian egg formation, mesoderm induction, neural induction, and patterning of the nervous system at the molecular level. Control of transcription, post-transcriptional control of gene expression (including control of RNA turnover and RNA localization). Research Review in Genetics and Development: Mechanisms of Gene Control in Vertebrate Animals: Read More [+]
Rules & Requirements
Prerequisites: Enrollment is restricted to students conducting research in the laboratory of the instructor, or requires consent of instructor
Repeat rules: Course may be repeated for credit without restriction.
Hours & Format
Fall and/or spring: 15 weeks - 2 hours of seminar per week
Additional Details
Subject/Course Level: Molecular and Cell Biology/Graduate
Grading: Offered for satisfactory/unsatisfactory grade only.
Terms offered: Spring 2024, Spring 2023, Spring 2022
Molecular and cellular analysis of the immune response emphasizing concepts and methodology. Innate immunity, pathogen sensors, antibodies and T cell receptors, lymphocyte activation, tolerance and selection. Antigen processing, T cell subtypes, and T regulatory cells. NK cells, tumor surveillance, and AIDS. Advanced Immunology: Read More [+]
Rules & Requirements
Prerequisites: 100, 110, 140, 150 or consent of instructor
Hours & Format
Fall and/or spring: 15 weeks - 3 hours of lecture and 1 hour of discussion per week
Additional Details
Subject/Course Level: Molecular and Cell Biology/Graduate
Terms offered: Spring 2022, Spring 2021, Fall 2020
This is an advanced seminar course which will consider current research questions and experimental approaches in molecular and cellular immunology. Each registrant will present a 30-minute research talk describing the problems they are studying, the approach they are taking, their preliminary data, and technical problems. Other course participants (including basic immunology faculty) will provide criticism and suggestions. The Regulation of Immune System Development and Function: Read More [+]
Rules & Requirements
Prerequisites: 250 or consent of instructor
Hours & Format
Fall and/or spring: 15 weeks - 1 hour of lecture per week
Additional Details
Subject/Course Level: Molecular and Cell Biology/Graduate
Grading: Offered for satisfactory/unsatisfactory grade only.
Terms offered: Fall 2024, Spring 2024, Fall 2023
The TB field has entered a new era with the convergence of genetic tools, genome sequencing, bioinformatics, advanced imaging techniques, animal models of infection, and high-throughput assays that allow us to study this multi-faceted interaction between Mtb and its host. We use all of these tools to probe the molecular and cellular events that enable M. tuberculosis to evade host defense mechanisms. Mycobacterium Tuberculosis (Mtb): Read More [+]
Rules & Requirements
Prerequisites: Enrollment is restricted to students conducting research in the laboratory of the instructor, or requires consent of instructor
Repeat rules: Course may be repeated for credit without restriction.
Hours & Format
Fall and/or spring: 15 weeks - 2 hours of seminar per week
Additional Details
Subject/Course Level: Molecular and Cell Biology/Graduate
Grading: Offered for satisfactory/unsatisfactory grade only.
Terms offered: Fall 2024, Spring 2024, Fall 2023
We will discuss macrophage biology and innate immunity in the context of infection with *Mycobacterium tuberculosis* through
discussion of current research from the Stanley Lab and both cutting edge and classic literature in relevant fields.
Terms offered: Fall 2024, Spring 2024, Fall 2023
We will discuss circadian rhythms research, at the behavioral, tissue and molecular scales. Our main focus is the circadian regulation of gene expression and its impact in host physiology. We will also focus on malaria and sleeping sickness infections, understanding the clinical aspects, the immune response to parasites and the vector transmission. Research Review in Immunology and Pathogenesis: Circadian rhythms in Parasitic Diseases: Read More [+]
Rules & Requirements
Prerequisites: Enrollment is restricted to students conducting research in the laboratory of the instructor, or requires consent of instructor
Repeat rules: Course may be repeated for credit without restriction.
Hours & Format
Fall and/or spring: 15 weeks - 2 hours of seminar per week
Additional Details
Subject/Course Level: Molecular and Cell Biology/Graduate
Grading: Offered for satisfactory/unsatisfactory grade only.
Terms offered: Fall 2023, Fall 2022, Fall 2021
This course covers the molecular/cellular basis of neuron excitability (membrane potentials, action potential generation and propagation, ion channels), synaptic transmission and plasticity, sensory receptor function, and developmental neurobiology. Cellular and Developmental Neurobiology: Read More [+]
Hours & Format
Fall and/or spring: 15 weeks - 3 hours of lecture per week
Additional Details
Subject/Course Level: Molecular and Cell Biology/Graduate
Terms offered: Fall 2024, Spring 2024, Fall 2023
Research in our laboratory focuses on understanding how neurons use biochemical pathways to integrate diverse types of information in order to adjust synaptic strength and modulate neuronal excitability, and how these interactions go awry in disease. To investigate this we are taking a multi-disciplinary approach incorporating molecular, biochemical, imaging, and electrophysiological analyses in mouse and human cells. Research Review in Neurobiology: Molecular Mechanisms of Neuronal Plasticity: Read More [+]
Rules & Requirements
Prerequisites: Enrollment is restricted to students conducting research in the laboratory of the instructor, or requires consent of instructor
Repeat rules: Course may be repeated for credit without restriction.
Hours & Format
Fall and/or spring: 15 weeks - 2 hours of seminar per week
Additional Details
Subject/Course Level: Molecular and Cell Biology/Graduate
Grading: Offered for satisfactory/unsatisfactory grade only.
Terms offered: Fall 2024, Spring 2024, Fall 2023
Review of research in molecular and biophysical aspects of sensory transduction and electrical signaling in the nervous system. Molecular and Biophysical Neuroscience: Read More [+]
Rules & Requirements
Prerequisites: Enrollment is restricted to students conducting research in the laboratory of the instructor, or requires consent of the instructor
Repeat rules: Course may be repeated for credit without restriction.
Hours & Format
Fall and/or spring: 15 weeks - 2 hours of seminar per week
Additional Details
Subject/Course Level: Molecular and Cell Biology/Graduate
Grading: Offered for satisfactory/unsatisfactory grade only.
Terms offered: Fall 2024, Spring 2024, Fall 2023
Research review in neurobiology. Review of recent optogenetic strategies for dissecting neural connectivity, function, and dysfunction in the rodent and primate brain. Optogenetic Dissection of Neural Circuits: Read More [+]
Rules & Requirements
Prerequisites: Enrollment is restricted to students conducting research in the laboratory of the instructor, or requires consent of instructor
Repeat rules: Course may be repeated for credit without restriction.
Hours & Format
Fall and/or spring: 15 weeks - 2 hours of seminar per week
Additional Details
Subject/Course Level: Molecular and Cell Biology/Graduate
Grading: Offered for satisfactory/unsatisfactory grade only.
Terms offered: Fall 2024, Spring 2024, Fall 2023
Research in the Fisher laboratory focuses on spatial navigation in fruit flies in order to understand how nervous systems flexibly process information. Our research combines in vivo electrophysiology, 2-photon imaging, advanced genetic approaches and quantitative behavioral analysis to understand how the fly’s brain constructs and maintains a sense of direction under ever-changing conditions.
Terms offered: Fall 2024, Spring 2024, Fall 2023
Mechanisms for visual object representation including recognition, memory, segmentation, tracking, 3D representation, and embedding into meaningful scenes. Understanding the function of feedforward and feedback pathways in vision. Research Review in Neurobiology: Visual Neuroscience: Read More [+]
Rules & Requirements
Prerequisites: Enrollment is restricted to students conducting research in the laboratory of the instructor, or requires consent of instructor
Repeat rules: Course may be repeated for credit without restriction.
Hours & Format
Fall and/or spring: 15 weeks - 2 hours of seminar per week
Additional Details
Subject/Course Level: Molecular and Cell Biology/Graduate
Grading: Offered for satisfactory/unsatisfactory grade only.
Terms offered: Fall 2024
This course offers an introduction to the field of biotechnology and will cover the history of the field, its impact on medicine and society, key methodologies, important therapeutic areas, and the range of career options available in the biopharmaceutical industry. Students will hear from lecturers with expertise ranging from molecular biology to clinical trial design and interpretation and be given an integrated overview of a complex area. Students will actively participate in experiential learning about relevant topics and presenting their findings in class, which will deepen understanding. There will be interactive elements, using a Socratic discussion format. Students are expected to participate actively. Therapeutics Development in Biotech: Financing, Regulation and Social Ethics: Read More [+]
Rules & Requirements
Prerequisites: Students must be enrolled in the Master of Biotechnology program
Hours & Format
Fall and/or spring: 15 weeks - 2 hours of lecture per week
Additional Details
Subject/Course Level: Molecular and Cell Biology/Graduate
Terms offered: Not yet offered
Automation plays an increasing role in academic and biotech labs. High-Throughput Screening (HTS) leverages screening of large libraries for activity against biological targets for drug discovery, enabled by automation, miniaturized assays and large-scale data analysis. Students learn process automation and hands-on training on sample management and liquid handling robotics. Students conduct a primary screen and follow up hits through dose response, using LIMS/Sample Management/Sample Tracking/Equipment Validation/QC and data analysis and interpretation. Students will understand what is required to run a HTS experiment, use robotics, data processing and control software, and learn how automation can help with accuracy and precision. Sample Management, Drug Discovery and Lab Automation: Read More [+]
Rules & Requirements
Prerequisites: This course will be limited to students enrolled in the MCB Master of Biotechnology program
Hours & Format
Fall and/or spring: 3 weeks - 10 hours of lecture and 20 hours of laboratory per week
Additional Details
Subject/Course Level: Molecular and Cell Biology/Graduate
Terms offered: Fall 2021, Spring 2020, Spring 2019
This course will cover several aspects of communicating quantitative information, with a primary focus on visualizations for publications, presentations, and posters. Other topics include sharing of data and analyses, such as new publication models and interactive notebooks, as well as lifecycle data management and publication. Primary discussion will be on conceptual issues, and students will be expected to use various systems and resources as self-directed homestudy. Communicating Quantitative Information: Read More [+]
Hours & Format
Fall and/or spring: 15 weeks - 1.5 hours of seminar and 1.5 hours of discussion per week
Additional Details
Subject/Course Level: Molecular and Cell Biology/Graduate
Terms offered: Spring 2022, Spring 2012, Spring 2011
The course will focus on fundamental principles, essential concepts, and recent advances in select topics in molecular and cell biology. Topics include genomics and computational biology, molecular evolution, neurons and synapses, microbi ology and immunology, macromolecular structure and function, and scientific writing. Courses are taught in tandem and maybe taken individually. Selected Topics in Molecular and Cell Biology: Read More [+]
Rules & Requirements
Prerequisites: Graduate standing or consent of instructor
Repeat rules: Course may be repeated for credit when topic changes.
Hours & Format
Fall and/or spring: 5 weeks - 3 hours of lecture and 1 hour of discussion per week
Additional Details
Subject/Course Level: Molecular and Cell Biology/Graduate
Terms offered: Spring 2012, Spring 2011, Spring 2010
The course will focus on fundamental principles, essential concepts, and recent advances in select topics in molecular and cell biology. Topics include genomics and computational biology, molecular evolution, neurons and synapses, microbi ology and immunology, macromolecular structure and function, and scientific writing. Courses are taught in tandem and maybe taken individually. Selected Topics in Molecular and Cell Biology: Read More [+]
Rules & Requirements
Prerequisites: Graduate standing and consent of instructor
Repeat rules: Course may be repeated for credit when topic changes.
Hours & Format
Fall and/or spring: 5 weeks - 3 hours of lecture and 1 hour of discussion per week
Additional Details
Subject/Course Level: Molecular and Cell Biology/Graduate
Terms offered: Spring 2022, Spring 2021, Spring 2016
The course will focus on fundamental principles, essential concepts, and recent advances in select topics in molecular and cell biology. Topics include genomics and computational biology, molecular evolution, neurons and synapses, microbi ology and immunology, macromolecular structure and function, and scientific writing. Courses are taught in tandem and maybe taken individually. Selected Topics in Molecular and Cell Biology: Read More [+]
Rules & Requirements
Prerequisites: Graduate standing and consent of instructor
Repeat rules: Course may be repeated for credit when topic changes.
Hours & Format
Fall and/or spring: 5 weeks - 3 hours of lecture and 1 hour of discussion per week
Additional Details
Subject/Course Level: Molecular and Cell Biology/Graduate
Terms offered: Fall 2024, Fall 2023, Fall 2022
The course will focus on fundamental principles, essential concepts, and recent advances in select topics in molecular and cell biology. Topics include genomics and computational biology, molecular evolution, neurons and synapses, microbi ology and immunology, macromolecular structure and function, and scientific writing. Courses are taught in tandem and maybe taken individually. Selected Topics in Molecular and Cell Biology: Read More [+]
Rules & Requirements
Prerequisites: Graduate standing or consent of instructor
Repeat rules: Course may be repeated for credit when topic changes.
Hours & Format
Fall and/or spring: 5 weeks - 3 hours of lecture and 1 hour of discussion per week
Additional Details
Subject/Course Level: Molecular and Cell Biology/Graduate
Terms offered: Spring 2012, Spring 2011, Spring 2010
The course will focus on fundamental principles, essential concepts, and recent advances in select topics in molecular and cell biology. Topics include genomics and computational biology, molecular evolution, neurons and synapses, microbi ology and immunology, macromolecular structure and function, and scientific writing. Courses are taught in tandem and maybe taken individually. Selected Topics in Molecular and Cell Biology: Read More [+]
Rules & Requirements
Prerequisites: Graduate standing and consent of instructor
Repeat rules: Course may be repeated for credit when topic changes.
Hours & Format
Fall and/or spring: 5 weeks - 3 hours of lecture and 1 hour of discussion per week
Additional Details
Subject/Course Level: Molecular and Cell Biology/Graduate
Terms offered: Fall 2016, Spring 2012, Spring 2011
The course will focus on fundamental principles, essential concepts, and recent advances in select topics in molecular and cell biology. Topics include genomics and computational biology, molecular evolution, neurons and synapses, microbi ology and immunology, macromolecular structure and function, and scientific writing. Courses are taught in tandem and maybe taken individually. Selected Topics in Molecular and Cell Biology: Read More [+]
Rules & Requirements
Prerequisites: Graduate standing and consent of instructor
Repeat rules: Course may be repeated for credit when topic changes.
Hours & Format
Fall and/or spring: 5 weeks - 3 hours of lecture and 1 hour of discussion per week
Additional Details
Subject/Course Level: Molecular and Cell Biology/Graduate
Terms offered: Spring 2022, Spring 2021, Spring 2020
Data science is rapidly becoming a critical skill for molecular and cell biologists. This course provides a survey of data science concepts and methods, including practical statistical inference and modeling, data visualization and exploration, elementary machine learning, and simulation. The course is practically oriented. Diverse real-world datasets, along with simulated data, will be used to develop skills and intuition. Data Science for Molecular and Cell Biology: Read More [+]
Rules & Requirements
Prerequisites: Graduate standing in the biological sciences or permission from instructors. Prior introductory exposure to programming is desired, e.g., through Data Science 8, MCB Python “boot camp,” or self taught from introductory programming tutorials. Please see http://python.berkeley.edu/resources/ for suggested resources. No prior statistics is assumed. The course is not suitable for students with advanced training in statistics or machine learning
Repeat rules: Course may be repeated for credit with instructor consent.
Hours & Format
Fall and/or spring: 15 weeks - 4 hours of lecture per week
Additional Details
Subject/Course Level: Molecular and Cell Biology/Graduate
Grading: Offered for satisfactory/unsatisfactory grade only.
Terms offered: Not yet offered
This capstone course fosters collaborative learning by bringing together students each week to discuss their internship project that they have been working on individually or in small groups under the supervision of their internship mentor. Students are encouraged to apply critical thinking skills to evaluate other projects and to provide constructive feedback. Students will work towards a final written report and oral presentation. They will identify and present a technology overview, explanation of unmet need, a central working hypothesis, a plan to test said hypothesis, execution of their plan, and a final research product. The final presentation will be in a poster presentation format. Master of Biotechnology Capstone Course: Read More [+]
Rules & Requirements
Prerequisites:MCELLBI 201A and MCELLBI 201B. Students must be enrolled in the Master of Biotechnology program
Hours & Format
Fall and/or spring: 15 weeks - 5 hours of seminar per week
Additional Details
Subject/Course Level: Molecular and Cell Biology/Graduate
Terms offered: Spring 2024, Fall 2023, Spring 2023
Graduate student presentations on selected research topics in molecular and cell biology. Several sections covering different topics offered each semester. Concurrent enrollment in more than one section is permitted. List of topics to be announced before each semester. Graduate Seminar: Read More [+]
Rules & Requirements
Prerequisites: Graduate standing in the department or consent of instructor
Repeat rules: Course may be repeated for credit without restriction.
Hours & Format
Fall and/or spring: 15 weeks - 1-2 hours of seminar per week
Additional Details
Subject/Course Level: Molecular and Cell Biology/Graduate
Terms offered: Fall 2024, Fall 2023, Fall 2022
Closely supervised experimental work under the direction of an individual faculty member; an introduction to experimental methods and research approaches in particular areas of molecular and cell biology. Introduction to Research: Read More [+]
Rules & Requirements
Prerequisites: Consent of instructor
Hours & Format
Fall and/or spring: 15 weeks - 2-12 hours of independent study per week
Additional Details
Subject/Course Level: Molecular and Cell Biology/Graduate
Grading: Letter grade. This is part one of a year long series course. A provisional grade of IP (in progress) will be applied and later replaced with the final grade after completing part two of the series.
Terms offered: Spring 2024, Spring 2023, Spring 2022
Closely supervised experimental work under the direction of an individual faculty member; an introduction to experimental methods and research approaches in particular areas of molecular and cell biology. Introduction to Research: Read More [+]
Rules & Requirements
Prerequisites: Consent of instructor
Hours & Format
Fall and/or spring: 15 weeks - 2-12 hours of independent study per week
Additional Details
Subject/Course Level: Molecular and Cell Biology/Graduate
Grading: Letter grade. This is part two of a year long series course. Upon completion, the final grade will be applied to both parts of the series.
Terms offered: Summer 2009 10 Week Session, Summer 2008 10 Week Session, Summer 2006 10 Week Session
Individual research under the supervision of a staff member. Research: Read More [+]
Rules & Requirements
Prerequisites: Consent of instructor
Repeat rules: Course may be repeated for credit without restriction.
Hours & Format
Summer: 8 weeks - 3-6 hours of independent study per week
Additional Details
Subject/Course Level: Molecular and Cell Biology/Graduate
Terms offered: Fall 2024, Fall 2023, Fall 2022
Seminar on presentation and evaluation of results in area of student's individual research interests. Research Seminar: Read More [+]
Rules & Requirements
Prerequisites: Concurrent enrollment in 291A or 292
Hours & Format
Fall and/or spring: 15 weeks - 3 hours of seminar per week
Additional Details
Subject/Course Level: Molecular and Cell Biology/Graduate
Grading: Offered for satisfactory/unsatisfactory grade only.
Terms offered: Spring 2024, Fall 2023, Spring 2023
The purpose of this course is to ensure that research trainees receive ample training in Responsible Conduct in Research. Students also gain an understanding of federal, state, and UC Berkeley policies and resources available to further support their research endeavors. Responsible Conduct in Research: Read More [+]
Rules & Requirements
Prerequisites: Consent of instructor
Repeat rules: Course may be repeated for credit without restriction.
Hours & Format
Fall and/or spring: 15 weeks - 1.5 hours of lecture and 1.5 hours of discussion per week
Additional Details
Subject/Course Level: Molecular and Cell Biology/Graduate
Grading: Offered for satisfactory/unsatisfactory grade only.
Terms offered: Prior to 2007
The purpose of this course is to ensure that research trainees receive training in Rigor and Reproducibility in Research. Students also gain an understanding of federal, state, and UC Berkeley policies and resources available to further support their research endeavors. Rigor and Reproducibility in Research: Read More [+]
Rules & Requirements
Prerequisites: Consent of Instructor
Hours & Format
Fall and/or spring: 15 weeks - 1.5 hours of lecture per week
Additional Details
Subject/Course Level: Molecular and Cell Biology/Graduate
Grading: Offered for satisfactory/unsatisfactory grade only.
Terms offered: Prior to 2007
This refresher course will cover topics in responsible conduct in research drawing from case studies of the Association of American Medical Colleges and the NIH. Students will review case studies in preparation for class discussion. Required of all 4th year MCB graduate students funded on NIH training grants. Responsible Conduct of Research Refresher: Read More [+]
Objectives & Outcomes
Course Objectives: Collaborative research including collaborations with industry Data acquisition and laboratory tools; management, sharing and ownership Mentor/mentee responsibilities and relationships Policies regarding human subjects, live vertebrate animal subjects in research, and safe laboratory
practices Research misconduct and policies for handling misconduct Responsible authorship and publication The scientist as a responsible member of society, contemporary ethical issues in biomedical research, and
the environmental and societal impacts of scientific research
Rules & Requirements
Prerequisites: Consent of instructor. Must be a 4th year MCB graduate student
Hours & Format
Fall and/or spring: 15 weeks - 1 hour of seminar per week
Additional Details
Subject/Course Level: Molecular and Cell Biology/Graduate
Grading: Offered for satisfactory/unsatisfactory grade only.
Terms offered: Fall 2018, Spring 2018
This course is designed to introduce students to the foundations of statistics in the context of biological research. Rather than focusing on a catalog of specific methods (by essence non-exhaustive and rapidly outdated), the course emphasizes general concepts and approaches necessary for sound statistical practice. Topics covered include: exploratory data analysis (EDA); data visualization; inferential reasoning; models and assumptions; statistical computing; computationally reproducible research. The statistical methods and software are motivated by and illustrated on data structures that arise in current biological and medical research. Foundations of Biostatistical Practice: Read More [+]
Rules & Requirements
Prerequisites: Consent of instructor
Hours & Format
Fall and/or spring: 15 weeks - 1 hour of lecture and 1 hour of discussion per week
Additional Details
Subject/Course Level: Molecular and Cell Biology/Graduate
Grading: Offered for satisfactory/unsatisfactory grade only.
Terms offered: Fall 2022, Fall 2021, Spring 2021
This course will discuss cutting-edge topics in biochemistry, structural biology, cell biology, developmental biology and genetics. Lectures will be given by internationally recognized biomedical scientists that visit the Molecular and Cell Biology Department and present work currently performed in their laboratories. The class will include topics ranging from structural analysis of important signaling molecules, live cell imaging and high resolution microscopy of critical cellular structures, to genetic dissection of essential signaling networks in cells and developmental pathways in multicellular organisms. It is the goal of this class to expose students to both the breadth and highest standards of current biomedical research. Current Topics in Biomedical Sciences: Read More [+]
Rules & Requirements
Prerequisites: Molecular and Cell Biology graduate students only
Repeat rules: Course may be repeated for credit without restriction.
Hours & Format
Fall and/or spring: 15 weeks - 2 hours of lecture per week
Additional Details
Subject/Course Level: Molecular and Cell Biology/Graduate
Grading: Offered for satisfactory/unsatisfactory grade only.
Terms offered: Spring 2024, Spring 2023, Spring 2022
This course is designed to assist graduate students in the biological sciences with planning their postgraduate careers. Weekly guest speakers will present their experiences on a variety of topics. Postdoctoral students are invited. Topics may include academia; job searches; setting up a laboratory; patent law/technology transfer; public policy/regulatory affairs; bioinformatics; science writing/technical support; forensic science; postdoctoral positions in industry; teaching, and other topics of interest. Careers for Life Sciences Ph.D's: Read More [+]
Rules & Requirements
Prerequisites: Open to graduate and postdoctoral students
Hours & Format
Fall and/or spring: 15 weeks - 2 hours of seminar per week
Additional Details
Subject/Course Level: Molecular and Cell Biology/Graduate
Grading: Offered for satisfactory/unsatisfactory grade only.
Terms offered: Spring 2024, Fall 2022, Fall 2021
This interactive seminar builds skills, knowledge and community in computational biology for first year PhD and second year Designated Emphasis students. Topics covered include concepts in human genetics/genomics, microbiome data analysis, laboratory methodologies and data sources for computational biology, workshops/instruction on use of various bioinformatics tools, critical review of current research studies and computational methods, preparation for success in the PhD program and career development. Faculty members of the graduate program in computational biology and scientists from other institutions will participate. Topics will vary each semester. Doctoral Seminar in Computational Biology: Read More [+]
Rules & Requirements
Repeat rules: Course may be repeated for credit without restriction.
Hours & Format
Fall and/or spring: 15 weeks - 2 hours of seminar per week
Additional Details
Subject/Course Level: Molecular and Cell Biology/Graduate
Terms offered: Prior to 2007
This course introduces new graduate student instructors to effective teaching methods that they can use in their MCB courses. Through readings, discussions and demonstrations, students will learn how to engage and motivate students, facilitate active participation, plan a class period, and write exam or practice problems. Emphasis will be placed on science education literature and proven practical techniques. We will also provide support and solutions for dealing with difficult situations that may come up during the semester. Pedagogy for MCB Graduate Student Instructors: Read More [+]
Rules & Requirements
Prerequisites: Appointment as graduate student instructor or consent of instructor
Hours & Format
Fall and/or spring: 10 weeks - 1 hour of seminar per week
Additional Details
Subject/Course Level: Molecular and Cell Biology/Professional course for teachers or prospective teachers
Grading: Offered for satisfactory/unsatisfactory grade only.
Terms offered: Fall 2022, Spring 2016, Fall 2015
Teaching laboratories and/or discussions for Molecular and Cell Biology courses: analysis of specific format and problems. Two units of credit for those with 50% teaching appointment; one unit of credit for those with 25% teaching appointment. Teaching of Molecular and Cell Biology: Read More [+]
Rules & Requirements
Prerequisites: Appointment as graduate student instructor or consent of instructor
Repeat rules: Course may be repeated for credit up to a total of 4 units.
Hours & Format
Fall and/or spring: 15 weeks - 0-1 hours of seminar per week
Additional Details
Subject/Course Level: Molecular and Cell Biology/Professional course for teachers or prospective teachers
Grading: Offered for satisfactory/unsatisfactory grade only.
Terms offered: Spring 2006, Spring 2005, Fall 2004
Individual study in consultation with the major field adviser. Intended to provide an opportunity for qualified students to prepare themselves for the various examinations required of candidates for the Ph.D. Individual Study for Doctoral Students: Read More [+]
Rules & Requirements
Prerequisites: Restricted to Ph.D. candidates
Credit Restrictions: Course does not satisfy unit or residence requirements for doctoral degree.
Repeat rules: Course may be repeated for credit without restriction.
Hours & Format
Fall and/or spring: 15 weeks - 0 hours of independent study per week
Summer: 6 weeks - 1-8 hours of independent study per week 8 weeks - 1-8 hours of independent study per week
Additional Details
Subject/Course Level: Molecular and Cell Biology/Graduate examination preparation
Grading: Offered for satisfactory/unsatisfactory grade only.
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