Computational Biology

University of California, Berkeley

This is an archived copy of the 2015-16 guide. To access the most recent version of the guide, please visit http://guide.berkeley.edu.

Overview

Computational biology is an academic growth area that binds together multiple areas of biological research with the mathematical and computational sciences. It takes center stage in the new data-oriented biology by facilitating scientific discoveries based on high-throughput methods. The genomic revolution has fundamentally changed the biological sciences, and computational biology provides the means for translation of genomic discoveries into a new understanding of complex biological systems and eventually into improvements of the human condition through development of solutions to environmental problems, new drug discoveries, and personalized medicine.

The Center for Computational Biology is Berkeley’s hub for research and training in computational biology and bioinformatics. Through courses, seminars, scientific meetings, and innovative training programs for PhD students administered by the Graduate Group in Computational Biology, the center catalyzes biological discoveries at the interface of biology, computation, and mathematics/statistics. As a campus strategic initiative, the center fosters an interactive, innovative, and collegiate environment for faculty, students, and postdoctorates drawn from five colleges and over a dozen academic departments. Faculty research interests are likewise diverse, ranging from computational and statistical genomics to population, comparative, and functional genomics; from bioinformatics and proteomics to evolutionary biology, phylogenomics, and statistical and computational methods development for modeling biological systems.

Undergraduate Programs

There is no undergraduate program in Computational Biology.

Graduate Programs

Computational Biology : Designated Emphasis (DE), PhD

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Courses

Computational Biology

CMPBIO 98BC Berkeley Connect in Computational Biology 1 Unit

Terms offered: Fall 2017, Spring 2017, Fall 2016
Berkeley Connect is a mentoring program, offered through various academic departments, that helps students build intellectual community. Over the course of a semester, enrolled students participate in regular small-group discussions facilitated by a graduate student mentor (following a faculty-directed curriculum), meet with their graduate student mentor for one-on-one academic advising, attend lectures and panel discussions featuring department
faculty and alumni, and go on field trips to campus resources. Students are not required to be declared majors in order to participate. Course may be repeated.

CMPBIO 175 Introduction to Computational Biology and Precision Medicine 3 Units

Terms offered: Summer 2017 Second 6 Week Session
Computational biology is an interdisciplinary field that develops and/or applies computational methods including bioinformatics to analyze large collections of biological data such as genomic data with a goal of making new predictions or discoveries. Precision medicine is an emerging approach for human disease treatment and prevention that takes into account individual variability in genes, environment, and lifestyle for each person. Computational
biology and bioinformatics tools are critical for advancing precision medicine. This survey course introduces computational tools for the analysis of genomic data and approaches to understanding and advancing precision medicine.

CMPBIO 198BC Berkeley Connect in Computational Biology 1 Unit

Terms offered: Fall 2017, Spring 2017, Fall 2016
Berkeley Connect is a mentoring program, offered through various academic departments, that helps students build intellectual community. Over the course of a semester, enrolled students participate in regular small-group discussions facilitated by a graduate student mentor (following a faculty-directed curriculum), meet with their graduate student mentor for one-on-one academic advising, attend lectures and panel discussions featuring department
faculty and alumni, and go on field trips to campus resources. Students are not required to be declared majors in order to participate. Course may be repeated.

CMPBIO 201 Classics in Computational Biology 3 Units

Terms offered: Fall 2017, Fall 2016, Fall 2015
Research project and approaches in computational biology. An introducton to the diverse ways biological problems are investigated computationally through critical evaluation of the classics and recent peer-reviewed literature. This is the core course required of all Computational Biology graduate students.

CMPBIO 290 Special Topics - Computational Biology 1 - 4 Units

Terms offered: Spring 2017, Spring 2016, Spring 2015
A graduate seminar class in which students closely examine recent computational methods in molecular and systems biology, for example for modeling mechanisms related to the regulation of gene expression and/or high-throughput sequencing data. The course will focus on computational methodology but will also cover relevant and interesting biological applications.

CMPBIO 293 Doctoral Seminar in Computational Biology 2 Units

Terms offered: Fall 2017, Spring 2017, Fall 2016
This one-year interactive seminar builds skills, knowledge and community in computational biology for first year PhD and second year Designated Emphasis students. Topics covered include concepts in human genetics/genomics, laboratory methodologies and data sources for computational biology, workshops/instruction on use of various bioinformatics tools, critical review of current research studies and computational methods, preparation for success
in the PhD program and career development. Faculty members of the graduate program in computational biology and scientists from other institutions will participate. Topics will vary each semester.

CMPBIO 294A Introduction to Research in Computational Biology 2 - 12 Units

Terms offered: Fall 2017, Fall 2016, Fall 2015
Closely supervised experimental or computational work under the direction of an individual faculty member; an introduction to methods and research approaches in particular areas of computational biology.

CMPBIO 294B Introduction to Research in Computational Biology 2 - 12 Units

Terms offered: Spring 2017, Spring 2016, Spring 2015
Closely supervised experimental or computational work under the direction of an individual faculty member; an introduction to methods and research approaches in particular areas of computational biology.

CMPBIO 295 Individual Research for Doctoral Students 1 - 12 Units

Terms offered: Fall 2017, Summer 2017 10 Week Session, Spring 2017
Laboratory research, conferences. Individual research under the supervision of a faculty member.

CMPBIO 477 Introduction to Programming for Bioinformatics Bootcamp 1.5 Unit

Terms offered: Summer 2017, Summer 2015 3 Week Session
The goals of this course are to introduce students to Python, a simple and powerful programming language that is used for many applications, and to expose them to the practical bioinformatic utility of Python and programming in general. The course will allow students to apply programming to the problems that they face in the lab and to leave this course with a sufficiently generalized knowledge of programming (and the confidence to read
the manuals) that they will be able to apply their skills to whatever projects they happen to be working on.

Faculty and Instructors

Faculty

Doris Bachtrog, Associate Professor. Evolution of sex and recombination, Y degeneration, dosage compensation, sexually antagonistic variation.
Research Profile

Lisa F. Barcellos, Associate Professor. Public health, genetic epidemiology, human genetics, autoimmune diseases, multiple schlerosis, lupus erythematosus, rheumatoid arthritis, epigenetics, genomics, computational biology.
Research Profile

Steven Brenner, Professor. Molecular biology, computational biology, evolutionary biology, bioengineering, structural genomics, computational genomics, cellular activity, cellular functions, personal genomics.
Research Profile

Sandrine Dudoit, Professor. Genomics, classification, statistical computing, biostatistics, cross-validation, density estimation, genetic mapping, high-throughput sequencing, loss-based estimation, microarray, model selection, multiple hypothesis testing, prediction, RNA-Seq.
Research Profile

Michael B. Eisen, Professor. Genomics, genome sequencing, bioinformatics, animal development.
Research Profile

Oskar Hallatschek, Assistant Professor.

Haiyan Huang, Associate Professor. Applied statistics, functional genomics, translational bioinformatics, high dimensional and integrative genomic/genetic data analysis, network modeling, hierarchical multi-lable classification.
Research Profile

Nicholas Ingolia, Assistant Professor. Ribosome Profiling, translation, genomics.
Research Profile

Michael I. Jordan, Professor. Computer science, artificial intelligence, bioinformatics, statistics, machine learning, electrical engineering, applied statistics, optimization.
Research Profile

Rasmus Nielsen, Professor. Statistical and computational aspects of evolutionary theory and genetics.
Research Profile

Lior Pachter, Professor. Mathematics, applications of statistics, combinatorics to problems in biology.
Research Profile

Jasper D. Rine, Professor. Biology, cell biology, DNA replication, gene regulation, saccharomyces cerevisiae, genetic analysis, genome, cholesterol biosynthetic pathway, modification of proteins, prenylated proteins.
Research Profile

Kimmen Sjolander, Professor. Computational biology, algorithms, phylogenetic tree reconstruction, protein structure prediction, multiple sequence alignment, evolution, bioinformatics, hidden Markov models, metagenomics, statistical modeling, phylogenomics, emerging and neglected diseases, machine-learning, genome annotation, metagenome annotation, systems biology, functional site prediction, ortholog identification.
Research Profile

Contact Information

Computational Biology Graduate Group

574 Stanley Hall

Phone: 510-642-0379

Fax: 510-666-3399

compbiograd@berkeley.edu

Visit Group Website

Department Chair

Steven Brenner, PhD (Plant and Microbial Biology)

461A Koshland Hall

Phone: 510-643-9131

brenner@compbio.berkeley.edu

Head Graduate Adviser

Lisa Barcellos, PhD (Public Health)

324 Stanley Hall

Phone: 510-642-7814

lbarcellos@genepi.berkeley.edu

Graduate Program Coordinator

Kate Chase

574 Stanley Hall, MC 3220

Phone: 510-642-0379

katechase@berkeley.edu

Adminstrative Director, CCB

Xuan Quach

174 Stanley Hall MC #3220

Phone: 510-666-3342

Fax: 510-666-3399

xuquach@berkeley.edu

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