Molecular and Cell Biology

University of California, Berkeley

This is an archived copy of the 2014-15 guide. To access the most recent version of the guide, please visit http://guide.berkeley.edu/.

Overview

The teaching and research activities of the Department of Molecular and Cell Biology (MCB) concern the molecular structures and processes of cellular life and their roles in the function, reproduction, and development of living organisms. This agenda covers a broad range of specialized disciplines, such as biochemistry, microbiology, biophysics, molecular biology, genetics, genomics, bioinformatics, cell biology, developmental biology, immunology, tumor biology and neurobiology. The types of living organisms from which the departmental faculty draws its working materials are as diverse as its disciplinary specializations, ranging from viruses and microbes through plants, roundworms, annelids, arthropods, and mollusks to fish, amphibia, and mammals. The faculty of the department is organized into five divisions: Biochemistry, Biophysics, and Stuctural Biology; Cell and Developmental Biology; Genetics, Genomics and Development; Immunology and Pathogenesis; and Neurobiology.

Research Facilities

The Cancer Research Laboratory is a research institute on the Berkeley campus that carries on a research, teaching, and service program designed to foster interdepartmental participation in cancer research. Some of the Department of Molecular and Cell Biology faculty are also members of the Cancer Research Laboratory. The central research program represents a multidisciplinary approach to an understanding of the mechanism of neoplastic transformation using a variety of systems. Graduate student and postdoctoral research programs are supported in various areas of tumor biology, biochemistry, cell biology, endocrinology, genetics, immunology, molecular biology, and tumor virology. The Cancer Research Laboratory also operates five research facilities:

  1. Flow Cytometry Facility for fluorescence activated cell sorting and analysis
  2. Molecular Imaging Facility with two-photon microscopes for image analysis
  3. Proteomic Mass Spectrometry Facility
  4. Immunology DNA Microarray Consortium
  5. Gene Targeting Facility for construction of transgenic and chimeric mice

Instrumentation in the facilities is operated by highly trained staff, and training is offered in methods and techniques associated with each facility. For more information, go to this website .

The Functional Genomics Laboratory at Berkeley was established to allow Berkeley scientists to exploit profound technological advances in the field of genomics. These advances, which include the sequencing of entire genomes of selected model systems and the ability to survey genome-wide patterns of gene expression, now allow the dissection of biological processes at unprecedented levels of detail. In particular, this research facility provides the infrastructure, technologies, and computational resources for the performance of DNA microarray experiments, which allow the analysis of mRNA expression from tens of thousands of genes at a time. The Functional Genomics Laboratory currently possesses all the equipment necessary for conducting DNA microarray experiments, including thermal cyclers, fluidics robots, microarray printing robots, laser scanning microscopes for microarray scanning, an Affymetrix workstation and scanner, and dedicated computers for data analysis and storage of informatics databases. For more information, go to this website .

The Robert D. Ogg Electron Microscope Laboratory is an instructional and research unit of the College of Letters and Science. It houses equipment for transmission electron microscopy (TEM) and scanning electron microscopy (SEM). The staff is skilled not only in the operation and maintenance of instruments but in standard and most specialized techniques of sample preparation. Qualified undergraduates and graduate students, postdoctoral associates, faculty, and research staff in biological and physical sciences, once trained, may make arrangements for use of the instruments in research. Instruction is provided in the form of both classes and individual training. Training is provided as MCB 481B and/or 481C. Registered students and faculty are not charged for training. Nominal charges are made for use of the laboratory for individual research work. With permission from the director, non-UC personnel can be accepted for training or laboratory use. Equipment can be used outside normal hours. The laboratory provides demonstrations of the electron microscope and preparative techniques for on-campus classes and can make special arrangements for tour groups. For more information, go to this website .

Other specialized research facilities include those for x-ray crystallography, nuclear magnetic resonance studies, large-scale fermentation, tissue culture, and DNA sequencing.

The Berkeley Screening Center is a campus-wide facility enabling Berkeley researchers to perform high-throughput genetic and chemical screens. The BSC provides automation, including automated image-acquisition, microscopy, and high-throughput liquid handling technology; support for screen execution and analysis; bioinformatic tools; and siRNA libraries targeting Drosophila, mouse, and human genomes, kinomes, and ubiquitinomes.

Undergraduate Programs

Molecular and Cell Biology: Biochemistry and Molecular Biology : BA
Molecular and Cell Biology: Cell and Developmental Biology : BA
Molecular and Cell Biology: Genetics, Genomics, and Development : BA
Molecular and Cell Biology: Immunology and Pathogenesis : BA
Molecular and Cell Biology: Neurobiology : BA

Graduate Program

Molecular and Cell Biology : PhD

Visit Department Website

Courses

Molecular and Cell Biology

MCELLBI 15 Current Topics in the Biological Sciences 2 Units

Students in this course will critically examine modern methods of biological investigations and their social implications. Relevant literature will be used to present basic biological concepts that address the cultural, technological and health aspects of current topics in the biological sciences. Designing and evaluating scientific questions will be stressed.

MCELLBI C31 Big Ideas in Cell Biology 3 Units

An introduction for students who do not intend to major in biology but who wish to satisfy their breadth requirement in Biological Sciences. Some major concepts of modern biology, ranging from the role of DNA and the way cells communicate, to interactions of cells and creatures with their environment, will be discussed without jargon and with attention to their relevance in contemporary life and culture.

MCELLBI 32 Introduction to Human Physiology 3 Units

A comprehensive introduction to human cell biology. The course will concentrate on basic mechanisms underlying human life processes, including cells and membranes; nerve and muscle function; cardiovascular, respiratory, renal, and gastrointestinal physiology; metabolism, endocrinology, and reproduction.

MCELLBI 32L Introduction to Human Physiology Laboratory 2 Units

Experiments and demonstrations are designed to amplify and reinforce information presented in 32. Exercises include investigations into the structure and function of muscle, nerve, cardiovascular, renal, respiratory, endocrine, and blood systems.

MCELLBI 41 Genetics and Society 3 Units

Basic communication of inheritance; gene mapping; gene expression and genetic disease in animals and humans; social inheritance of genetics.

MCELLBI C44 Biology for Voters 3 Units

This is a Discovery Course for non-Biology majors designed to introduce lower-division college students to biology through the lens of the contemporary problems facing people, the planet and the species of the planet. Modern genetic contributions will be presented on such issues as genetic engineering of plants and animals, the emergence of new pathogens, the role of genetic variation among individuals, and the extent to which DNA is and isn’t destiny. Each week will close with the presentation and discussion of a defining biological challenge facing the world.

MCELLBI 50 The Immune System and Disease 3 Units

Course will discuss how the immune system resolves, prevents, or causes disease. A general overview of the immune system will be covered in the first five weeks followed by five weeks discussing infectious diseases including anthrax, mad cow, herpes, malaria, tuberculosis, and HIV. In addition, other lectures will focus on current immunology topics including vaccines, autoimmunity, allergy, transplantation, and cancer.

MCELLBI 55 Plagues and Pandemics 3 Units

Discussion of how infectious agents cause disease and impact society at large. We will examine historical and current examples of plagues and pandemics and consider the question of what we should do to ameliorate the impact of infectious disease in the future. The course is intended for non-majors and will begin by briefly providing necessary background in microbiology and immunology. The primary focus in each subsequent week, however, will be on discussing a particular infectious disease. The course will be broad in scope covering biological, historical, ethical and social implications of each disease.

MCELLBI C61 Brain, Mind, and Behavior 3 Units

Introduction to human brain mechanisms of sensation, movement, perception, thinking, learning, memory, and emotion in terms of anatomy, physiology, and chemistry of the nervous system in health and disease. Intended for students in the humanities and social sciences and others not majoring in the biological sciences.

MCELLBI W61 Brain, Mind, and Behavior 3 Units

This course deals with the structure and function of the human nervous system, with an emphasis on how brain physiology and chemistry are related to human behavior. This is a comprehensive introduction to the exciting field of contemporary neuroscience for students of all backgrounds and interests, including those from the humanities and social sciences, as well as physical and biological sciences. The Final Examination will be administered in a proctored setting. See Schedule of Classes for meeting information. This course is web-based.

MCELLBI C62 Drugs and the Brain 3 Units

The history, chemical nature, botanical origins, and effects on the human brain and behavior of drugs such as stimulants, depressants, psychedelics, analgesics, antidepressants, antipsychotics, steroids, and other psychoactive substances of both natural and synthetic origin. The necessary biological, chemical, and psychological background material for understanding the content of this course will be contained within the course itself.

MCELLBI 63 Introduction to Functional Neuroanatomy 3 Units

This course emphasizes beginning anatomy of the brain and spinal cord to individuals interested in understanding the dynamics of motor and sensory functions in the human body. Students in the Departments of Education, Psychology, and Integrative Biology, as well as students interested in medicine and the life sciences, are especially encouraged to attend.

MCELLBI C64 Exploring the Brain: Introduction to Neuroscience 3 Units

This course will introduce lower division undergraduates to the fundamentals of neuroscience. The first part of the course covers basic membrane properties, synapses, action potentials, chemical and electrical synaptic interactions, receptor potentials, and receptor proteins. The second part of the course covers networks in invertebrates, memory and learning behavior, modulation, vertebrate brain and spinal cord, retina, visual cortex architecture, hierarchy, development, and higher cortical centers.

MCELLBI 84B Sophomore Seminar 1 or 2 Units

Sophomore seminars are small interactive courses offered by faculty members in departments all across the campus. Sophomore seminars offer opportunity for close, regular intellectual contact between faculty members and students in the crucial second year. The topics vary from department to department and semester to semester. Enrollment limited to 15 sophomores.

MCELLBI 90A Freshman Seminars: Biochemistry and Molecular Biology 1 Unit

The Berkeley Seminar Program has been designed to provide new students with the opportunity to explore an intellectual topic with a faculty member in a small-seminar setting. Berkeley Seminars are offered in all campus departments, and topics vary from department to department and semester to semester.

MCELLBI 90B Freshman Seminars: Cell and Developmental Biology 1 Unit

The Berkeley Seminar Program has been designed to provide new students with the opportunity to explore an intellectual topic with a faculty member in a small-seminar setting. Berkeley Seminars are offered in all campus departments, and topics vary from department to department and semester to semester.

MCELLBI 90C Freshman Seminars: Genetics and Development 1 Unit

The Berkeley Seminar Program has been designed to provide new students with the opportunity to explore an intellectual topic with a faculty member in a small-seminar setting. Berkeley Seminars are offered in all campus departments, and topics vary from department to department and semester to semester.

MCELLBI 90D Freshman Seminars: Immunology 1 Unit

The Berkeley Seminar Program has been designed to provide new students with the opportunity to explore an intellectual topic with a faculty member in a small-seminar setting. Berkeley Seminars are offered in all campus departments, and topics vary from department to department and semester to semester.

MCELLBI 90E Freshman Seminars: Neurobiology 1 Unit

The Berkeley Seminar Program has been designed to provide new students with the opportunity to explore an intellectual topic with a faculty member in a small-seminar setting. Berkeley Seminars are offered in all campus departments, and topics vary from department to department and semester to semester.

MCELLBI 91D Immunology 2 - 4 Units

Freshman and sophomore seminars offer lower division students the opportunity to explore an intellectual topic with a faculty member and a group of peers in a small-seminar setting. These seminars are offered in all campus departments; topics vary from department to department and from semester to semester.

MCELLBI C96 Studying the Biological Sciences 1 Unit

Freshmen will be introduced to the "culture" of the biological sciences, along with an in-depth orientation to the academic life and the culture of the university as they relate to majoring in biology. Students will learn concepts, skills, and information that they can use in their major course, and as future science professionals. Restricted to freshmen in the biology scholars program.

MCELLBI 98 Directed Group Study 1 - 4 Units

Lectures and small group discussions focusing on topics of interest, varying from semester to semester.

MCELLBI 99 Supervised Independent Study 1 - 4 Units

MCELLBI 100B Biochemistry: Pathways, Mechanisms, and Regulation 4 Units

We survey cellular metabolic pathways, with focus on the underlying chemistry, bioenergetics, and mechanisms. We discuss signaling in the context of a physical chemical understanding of diffusion, transport and molecular interactions. We will highlight the intertwining of signaling and dysregulation with metabolic disorders and cancer, and the production of renewable chemicals such as biofuels. The course is designed for majors in the biochemistry and molecular biology, genetics and development, or immunology emphases.

MCELLBI C100A Biophysical Chemistry: Physical Principles and the Molecules of Life 4 Units

Thermodynamic and kinetic concepts applied to understanding the chemistry and structure of biomolecules (proteins, DNA, and RNA). Molecular distributions, reaction kinetics, enzyme kinetics. Bioenergetics, energy transduction, and motor proteins. Electrochemical potential, membranes, and ion channels.

MCELLBI 102 Survey of the Principles of Biochemistry and Molecular Biology 4 Units

A comprehensive survey of the fundamentals of biological chemistry, including the properties of intermediary metabolites, the structure and function of biological macromolecules, the logic of metabolic pathways (both degradative and biosynthetic) and the molecular basis of genetics and gene expression.

MCELLBI C103 Bacterial Pathogenesis 3 Units

This course for upper division and graduate students will explore the molecular and cellular basis of microbial pathogenesis. The course will focus on model microbial systems which illustrate mechanisms of pathogenesis. Most of the emphasis will be on bacterial pathogens of mammals, but there will be some discussion of viral and protozoan pathogens. There will be an emphasis on experimental approaches. The course will also include some aspects of bacterial genetics and physiology, immune response to infection, and the cell biology of host-parasite interactions.

MCELLBI 104 Genetics, Genomics, and Cell Biology 4 Units

This course will introduce students to key concepts in genetic analysis, eukaryotic cell biology, and state-of-the-art approaches in genomic medicine. Lectures will highlight basic knowledge of cellular processes with the basis for human diseases, particularly cancer. Prerequisite courses will have introduced students to the concepts of cells, the central dogma of molecular biology, and gene regulation. Emphasis in this course will be on eukaryotic cell processes, including cellular organization, dynamics, and signaling.

MCELLBI 110 Molecular Biology: Macromolecular Synthesis and Cellular Function 4 Units

Molecular biology of prokaryotic and eukaryotic cells and their viruses. Mechanisms of DNA replication, transcription, translation. Structure of genes and chromosomes. Regulation of gene expression. Biochemical processes and principles in membrane structure and function, intracellular trafficking and subcellular compartmentation, cytoskeletal architecture, nucleocytoplasmic transport, signal transduction mechanisms, and cell cycle control.

MCELLBI C110L General Biochemistry and Molecular Biology Laboratory 4 Units

Experimental techniques of biochemistry and molecular biology, designed to accompany the lectures in Molecular and Cell Biology 100B and 110.

MCELLBI C112 General Microbiology 4 Units

This course will explore the molecular bases for physiological and biochemical diversity among members of the two major domains, Bacteria and Archaea. The ecological significance and evolutionary origins of this diversity will be discussed. Molecular, genetic, and structure-function analyses of microbial cell cycles, adaptive responses, metabolic capability, and macromolecular syntheses will be emphasized.

MCELLBI C112L General Microbiology Laboratory 2 Units

Experimental techniques of microbiology designed to accompany the lecture in C112 and C148. The primary emphasis in the laboratory will be on the cultivation and physiological and genetic characterization of bacteria. Laboratory exercises will include the observation, enrichment, and isolation of bacteria from selected environments.

MCELLBI C114 Introduction to Comparative Virology 4 Units

This course will provide a comparative overview of virus life cycles and strategies viruses use to infect and replicate in hosts. We will discuss virus structure and classification and the molecular basis of viral reproduction, evolution, assembly, and virus-host interactions. Common features used during virus replication and host cellular responses to infection will be covered. Topics also included are common and emerging virus diseases, their control, and factors affecting their spread.

MCELLBI C116 Microbial Diversity 3 Units

This course for upper-division and graduate students will broadly survey myriad types of microbial organisms, both procaryote and eucaryote, using a phylogenetic framework to organize the concept of "biodiversity." Emphasis will be on the evolutionary development of the many biochemical themes, how they mold our biosphere, and the organisms that affect the global biochemistry. Molecular mechanisms that occur in different lineages will be compared and contrasted to illustrate fundamental biological strategies. Graduate students additionally should enroll in C216, Microbial Diversity Workshop.

MCELLBI 118 The Cancer Karyotype: What it is and What it Does 1 Unit

Mutational cancer theories do not explain why cancers: 1) have clonal individual karyotypes; 2) have polygenic transcriptomes and phenotypes; 3) have flexible karyotypes, which evolve progressive malignancy and drug resistance, but maintain autonomy and even immortality; and 4) Why carcinogens induce cancer only after conspicuously long latent periods of years to decades. To answer these questions, this course tests a new karyotypic theory, which postulates that cancers evolve much like new species.

MCELLBI 130A Cell and Systems Biology 4 Units

This course will provide a detailed discussion of a wide range of topics in cell biology emphasizing experimental approaches and key experiments that have provided important insights. The course is aimed at conveying an understanding of how cellular structure and function arise as a result of the properties of cellular macromolecules. An emphasis will be placed on the dynamic nature of cellular organization and will include a description of physical properties of cells (dimensions, concepts of free energy, diffusion, biophysical properties). Students will be introduced to quantitative aspects of cell biology and a view of cellular function that is based on integrating multiple pathways and modes of regulation (systems biology).

MCELLBI 132 Biology of Human Cancer 4 Units

The course is designed for students interested in learning about the molecular and cell biology of cancer and how this knowledge is being applied to the prevention, diagnosis and therapy of cancer. Topics covered include tumor pathology and epidemiology; tumor viruses and oncogenes; intracellular signaling; tumor suppressors; multi-step carcinogenesis and tumor progression; genetic instability in cancer; tumor-host interactions; invasion and metastasis; tumor immunology; cancer therapy.

MCELLBI 133L Physiology and Cell Biology Laboratory 4 Units

Experimental analyses of central problems in cell biology and physiology using modern techniques, including DNA cloning and protein biochemistry, fluorescence microscopy of the cytoskeleton and organelles, DNA transfection and cell cycle analysis of cultured mammalian cells, RNA interference and drug treatments to analyze ion channel function in cell contractility and intracellular signaling, and somatosensation.

MCELLBI C134 Chromosome Biology/Cytogenetics 3 Units

Survey of behavior, structure, and function of chromosomes with emphasis on behavior in model organisms. Topics include mitosis, meiosis, chromosome aberrations, genome function, dosage compensation, transposons, repetitive DNA, and modern cytological imaging.

MCELLBI 135A Topics in Cell and Developmental Biology: Molecular Endocrinology 3 Units

Molecular mechanisms by which hormones elicit specific responses and regulate gene expression; hormone-receptor interaction; synthesis, transport and targeting of hormones, growth factors and receptors.

MCELLBI 136 Physiology 4 Units

Principles of mammalian (primarily human) physiology emphasizing physical, chemical, molecular and cellular bases of functional biology. The following topics will be covered: cellular and membrane ion and nonelectrolyte transport; cell and endocrine regulation; autonomic nervous system regulation; skeletal, smooth and cardiac muscle; cardiovascular physiology; respiration; renal physiology; gastrointestinal physiology. Discussion section led by Graduate Student Instructor will review material covered in lecture.

MCELLBI 137 Computer Simulation in Biology 3 Units

Modeling and computer simulation of dynamic biological processes using special graphical interfaces requiring very little mathematical or computer experience. Models are drawn from the current literature to teach concepts and technique. The later part of the course is a workshop for student-selected individual projects. Computer work may be done at home or in the university laboratory.

MCELLBI 140 General Genetics 4 Units

In-depth introduction to genetics, including mechanisms of inheritance; gene transmission and recombination; transposable DNA elements; gene structure, function, and regulation; and developmental genetics. Some exams may be given in the evening.

MCELLBI 140 General Genetics 4 Units

In-depth introduction to genetics, including mechanisms of inheritance; gene transmission and recombination; transposable DNA elements; gene structure, function, and regulation; and developmental genetics. Some exams may be given in the evening.

MCELLBI 140L Genetics Laboratory 4 Units

Experimental techniques in classical and molecular genetics.

MCELLBI 141 Developmental Biology 4 Units

An introduction to principles and processes of embryonic and post-embryonic development, stressing mechanisms of cell and tissue interactions, morphogenesis and regulation of gene expression.

MCELLBI 143 Evolution of Genomes, Cells, and Development 3 Units

This course is intended for upper-division undergraduates seeking an interactive course based on modern concepts in evolution and comparative genomics. The course will emphasize the contribution of molecular evolution to a series of seminal events in life's history: origin of life; origin of cells; origin of eukaryotes; origin of multicellularity; evolution of animal development; human origins.

MCELLBI C148 Microbial Genomics and Genetics 4 Units

Course emphasizes bacterial and archaeal genetics and comparative genomics. Genetics and genomic methods used to dissect metabolic and development processes in bacteria, archaea, and selected microbial eukaryotes. Genetic mechanisms integrated with genomic information to address integration and diversity of microbial processes. Introduction to the use of computational tools for a comparative analysis of microbial genomes and determining relationships among bacteria, archaea, and microbial eukaryotes.

MCELLBI 149 The Human Genome 3 Units

This is an upper division course for majors in MCB with an interest in an in-depth exploration of the forces that shape the human genome and the human population, as well as the ways that human genetic information can be used in medicine, ancestry and forensics. The course will combine lectures and discussion of research papers.

MCELLBI 150 Molecular Immunology 4 Units

Fundamentals of immunology with emphasis on biochemical and molecular approaches to study of the immune system and its application in medicine and biotechnology. Topics covered include description of the immune system, antibody and T-cell receptor structure and function, genes of the immunoglobulin superfamily, cells and molecular mediators that regulate the immune response, allergy, autoimmunity, immunodeficiency, tissue and organ transplants, and tumor immunology.

MCELLBI 150L Immunology Laboratory 4 Units

Experimental techniques in mammalian molecular biology and cellular immunology. Molecular techniques covered include PCR and recombinant DNA procedures such as gene cloning, gene transfer, DNA sequencing, Southern blot, and restriction mapping. Immunological techniques covered include cell culture and monoclonal antibody production, flow cytometry, ELISA, immunoprecipitation, and western blot.

MCELLBI 160 Cellular and Molecular Neurobiology 4 Units

Comprehensive introductory survey of cellular and molecular neuroscience, including cellular neurophysiology, ion channel function, synaptic function and plasticity, sensory transduction, and brain development. Includes introduction to molecular basis of neurological disease. Analysis from the level of molecules to cells to simple circuits.

MCELLBI 160L Neurobiology Laboratory 4 Units

Experimental analyses of properties and interactions of nerve cells and systems, illustrating principal features and current methods. Techniques employed include computer simulation of neuron properties, electrophysiological recording and stimulation of nerves and cells, digitally enhanced video imaging of outgrowth, fluorescence immunocytochemistry, analysis of sensory: CNS mapping, human-evoked potential recording, sensory psychophysics.

MCELLBI 161 Circuit, Systems and Behavioral Neuroscience 4 Units

Comprehensive survey of circuits and systems neuroscience, including sensory and motor systems, learning and memory, neuromodulatory systems and brain state and higher functions.
Biological and computational principles of neural circuit function. Analysis from the level of small circuits to behavior.

MCELLBI 163 Mammalian Neuroanatomy 4 Units

Development, structure (gross and microscopic), and functional relationships of the mammalian nervous system.

MCELLBI 165 Neurobiology of Disease 3 Units

The molecular, cellular, and neural circuit basis of neurological disease. Includes neurochemistry and reward systems, neural development and its disorders, addiction, neurodegenerative and neuropsychiatric disorders. Students will read and discuss primary papers from the research literature.

MCELLBI 166 Biophysical Neurobiology 3 Units

Electrochemistry and ion transport phenomena, equivalent circuits, excitability, action potentials, voltage clamp and the Hodgkin-Huxley model. Biophysical properties of ion channels. Statistical and electrophysiological models of synaptic transmission, Quantitative models for dendritic structure and neuronal morphogenesis. Sensory transduction, cellular networks as computational devices, information processing and transfer.

MCELLBI 180 Undergraduate Teaching of Biology 1A Laboratory 1 or 2 Units

Course consists of a weekly three-hour training session that focuses on laboratory techniques, instructional aids, and problem solving, plus an additional three hour weekly laboratory where the UGSI is required to assist a GSI in the instruction of laboratory (answering questions, providing demonstrations, etc.).

MCELLBI 180C Undergraduate Teaching of Molecular and Cell Biology 32 Laboratory 1 - 2 Units

Course consists of a weekly three-hour training session that focuses on laboratory techniques, instructional aids, and problem solving, plus an additional three-hour weekly laboratory where the UGSI is required to assist a GSI in the instruction of laboratory (answering questions, providing demonstrations, etc.). Students will be graded on lecture and laboratory attendance and preparation of one quiz.

MCELLBI H196A Honors Research 1 - 4 Units

Individual research and thesis preparation under the supervision of a faculty member. Acceptance to the Molecular and Cell Biology Honors Program is required. Contact the MCB Undergraduate Affairs Office, 3060 Valley Life Sciences Building, for application and details. Honor students must complete at least two semesters of research, taking a minimum of 4 units and a maximum of 8 units of H196A-196B. If desired, one semester of 199 can be used to replace H196A.

MCELLBI H196B Honors Research 1 - 4 Units

Individual research and completion of thesis under the supervision of a faculty member. This course satisfies the thesis requirement for the Molecular and Cell Biology Department Honors Program. Contact the MCB Undergraduate Affairs Office, 3060 Valley Life Sciences Building, for program details and an application. Honor students must complete at least two semesters of research, taking a minimum of 4 units and a maximum of 8 units of H196A-196B. One semester of H196B is required.

MCELLBI 197 Supervised Internship 1 Unit

Supervised experience relevant to specific topics of biology in off-campus organizations. Written report and evaluation from internship supervisor required.

MCELLBI 198 Directed Group Study 1 - 4 Units

Lectures and small group discussions focusing on topics of interest, varying from semester to semester.

MCELLBI 199 Supervised Independent Study and Research 1 - 4 Units

Enrollment restrictions apply; see the Introduction to Courses and Curricula section of this catalog.

MCELLBI 200A Fundamentals of Molecular and Cell Biology 3 Units

The goal of this course is to provide graduate-level instruction on molecular and cellular biosciences from a highly-integrated systems perspective, rather than using a more classic, techniques-oriented format. A collection of approaches, and a focus on critical thinking and problem solving, will be used to show how fundamental, highly-significant biological problems are "cracked open." Reading will be assigned from a mix of classic and current peer-reviewed papers selected by the instructors.

MCELLBI 200B Fundamentals of Molecular and Cell Biology 3 Units

The goal of this course is to provide graduate-level instruction on molecular and cellular biosciences from a highly-integrated systems perspective, rather than using a more classic, techniques-oriented format. A collection of approaches, and a focus on critical thinking and problem solving, will be used to show how fundamental, highly-significant biological problems are "cracked open." Reading will be assigned from a mix of classic and current peer-reviewed papers selected by the instructors.

MCELLBI 206 Physical Biochemistry 3 Units

Application of modern physical concepts and experimental methods to the analysis of the structure, function, and interaction of large molecules of biological interest.

MCELLBI 210 Macromolecular Reactions and the Cell 4 Units

General course for first-year graduate students. Covers our current understanding of, methodological approaches for analyzing, and recent advances in the function of cellular macromolecules and macromolecular complexes in DNA replication, recombination, transposition and repair, gene expression and its regulation, mRNA splicing, genome organization, noncoding RNAs, signal transduction, protein synthesis, folding and degradation, growth control, and other life processes.

MCELLBI C212A Chemical Biology I - Structure, Synthesis and Function of Biomolecules 1 Unit

This course will present the structure of proteins, nucleic acids, and oligosaccharides from the perspective of organic chemistry. Modern methods for the synthesis and purification of these molecules will also be presented.

MCELLBI C212B Chemical Biology II - Enzyme Reaction Mechanisms 1 Unit

This course will focus on the principles of enzyme catalysis. The course will begin with an introduction of the general concepts of enzyme catalysis which will be followed by detailed examples that will examine the chemistry behind the reactions and the three-dimensional structures that carry out the transformations.

MCELLBI C212C Chemical Biology III - Contemporary Topics in Chemical Biology 1 Unit

This course will build on the principles discussed in Chemical Biology I and II. The focus will consist of case studies where rigorous chemical approaches have been brought to bear on biological questions. Potential subject areas will include signal transduction, photosynthesis, immunology, virology, and cancer. For each topic, the appropriate bioanalytical techniques will be emphasized.

MCELLBI C214 Protein Chemistry, Enzymology, and Bio-organic Chemistry 2 Units

The topics covered will be chosen from the following: protein structure; protein-protein interactions; enzyme kinetics and mechanism; enzyme design. Intended for graduate students in chemistry, biochemistry, and molecular and cell biology.

MCELLBI C216 Microbial Diversity Workshop 1 Unit

This workshop for graduate students will parallel C116, Microbial Diversity, which should be taken concurrently. Emphasis in the workshop will be on review of research literature and formulation of paper pertinent to research in microbial diversity.

MCELLBI 218C Research Review in Biochemistry and Molecular Biology: Synthetic Biology and Cellular Enzymology 2 Units

Synthetic biology, metabolic engineering, systems biology, enzyme mechanism, and gene discovery.

MCELLBI 218D Research Review in Biochemistry and Molecular Biology: Gene Regulation at the RNA Level 2 Units

RNA elements involved in alternative splicing and other co-transcriptional mechanisms of regulation. Specific areas of interest include riboswitches and other structured RNA elements involved in gene regulation.

MCELLBI 218E Research Review in Biochemistry and Molecular Biology: Viruses as Models for Eukaryote Gene Expression and Replication 2 Units

Recent developments in eukaryote viral and cellular regulation. New concepts in transcription and RNA replication, with particular emphasis on virus-cell interactions.

MCELLBI 218F Research Review in Biochemistry and Molecular Biology: Energy-dependent Proteases and Molecular Machines 2 Units

Our goals are to decipher the fundamental principles that govern substrate engagement, de-ubiquitylation, unfolding, and translocation by the proteasome.

MCELLBI 218G Research Review in Biochemistry and Molecular Biology: Myxobacterial Development 2 Units

Review of current literature and discussion of original research.

MCELLBI 218H Research Review in Biochemistry and Molecular Biology: Protein Synthesis in Bacteria and Mammals 2 Units

The mechanism of protein synthesis in bacteria and human cells. Specific areas of interest include the structure and function of the ribosome and the regulation of protein synthesis.

MCELLBI 218I Research Review in Biochemistry and Molecular Biology: Chemical Biology and Inorganic Chemistry 2 Units

Research and literature topics in chemical biology and inorganic chemistry relevant to human health and disease and energy science will be discussed.

MCELLBI 218J Research Review in Biochemistry and Molecular Biology: Advanced 20th Century Perspectives on Cancer Cell Genetics 2 Units

Transduction of cellular sequences and genetic regulation of transformation by oncogenic retroviruses as models for natural carcinogenesis, including a critical review of the current research.

MCELLBI 218O Research Review in Biochemistry and Molecular Biology: Chemical Biology and Enzymology 2 Units

Topics at the interface of chemistry and biology with a particular focus on mechanisms of enzyme catalysis.

MCELLBI 218P Research Review in Biochemistry and Molecular Biology: Chemical Biology and Neuroscience 2 Units

Molecular approaches to designing and deploying tools for voltage imaging and brain mapping.

MCELLBI 218Q Research Review in Biochemistry and Molecular Biology: Single Molecular Imaging of Macromolecular Enzymes 2 Units

Yildiz laboratory combines molecular biology and single molecule biophysical techniques to understand mechanisms that underlie cellular organization and motility. Specific focuses of the lab are to dissect 1) the mechanism of cytoplasmic dynein motility, 2) the regulation of intraflagellar transport, and 3) the protection and maintenance of mammalian telomeres.

MCELLBI 218R Research Review in Biochemistry and Molecular Biology: The Protein Folding Problem 2 Units

Protein structure, stability, design, and the pathway of protein folding.

MCELLBI 218S Research Review in Biochemistry and Molecular Biology: Cryo-Electron Microscopy of Macromolecules 2 Units

Structure-function studies of the cytoskeleton and large molecular machines by cryo-electron microscopy and image reconstruction.

MCELLBI 218V Research Review in Biochemistry and Molecular Biology: Biophysics of Macromolecule Transport Across Membranes 2 Units

Review of current literature and discussion of original research.

MCELLBI 218W Research Review in Biochemistry and Molecular Biology: Enzyme Catalysis 2 Units

Fundamental aspects of enzyme catalysis, as probed by kinetic, spectroscopic, and molecular biological approaches.

MCELLBI 218X Research Review in Biochemistry and Molecular Biology: Chemical Reactions of Metabolism 2 Units

Define how metabolic reactions function in the context of the cellular system in order to elucidate the so-called design principles of metabolic function.

MCELLBI 218Z Molecular and Cellular Mechanisms of Nutrient Sensing 2 Units

In our laboratory, we study the molecular mechanisms of nutrient sensing and growth control. Specific areas of interest include the mTOR pathway, energy sensing, lysosomal biology and translational control.

MCELLBI 219A Structural Membrane Biology 2 Units

The mechanisms by which protein complexes use their structures to bud, bend, and sever membranes will be covered in research reports and reviews of the current literature and in discussion of current experiments in the field.

MCELLBI 219B Regulation of Translation 2 Units

Understanding the molecular basis and physiological role of translational regulation in gene expression with an emphasis on global profiling and functional genomics.

MCELLBI 219F Research Review in Biochemistry and Molecular Biology: Eukaryotic Gene Expression 2 Units

Protein-DNA interactions and the control of gene expression in eukaryotes.

MCELLBI 219G Virus-Host Interactions 2 Units

Understanding the creative strategies viruses use to manipulate gene expression in host cells, with a focus on RNA-based regulation of gene expression.

MCELLBI 219H Research Review in Biochemistry and Molecular Biology: Molecular and Cell Biology of <Listeria monocytogenes> Pathogenesis 2 Units

Discussion of recent research on the genetics, cell biology, and immunology of the model facultative intracellular bacterical pathogen,

MCELLBI 219J Research Review in Biochemistry and Molecular Biology: Structure and Function of RNA 2 Units

RNA structure, folding, and function. Specific topics include ribozyme mechanisms, RNA-mediated translation initiation, and protein targeting and secretion.

MCELLBI 219Q Research Review in Biochemistry and Molecular Biology: Structural Biology of Molecular Machines 2 Units

Crystallographic and biochemical studies of protein machines, focused on protein-nucleic acid interactions; analysis of chemomechanical function within multiprotein complexes will be covered in research reports and reviews of the current literature and in discussion of current experiments in the field.

MCELLBI 219S Research Review in Biochemistry and Molecular Biology: Structural Biology of Signaling and Replication 2 Units

Mechanisms and structure in DNA replication and eukaryotic cell signaling.

MCELLBI 219T Research Review in Biochemistry and Molecular Biology: Signal Transduction Mechanisms 2 Units

Discussion of recent research on various aspects of signal transduction mechanisms in eukaryotic cells, including G protein-coupled receptors, protein kinase cascades, synthesis and mobilization of lipid mediators, calcium sensing and response pathways, activation and inhibition of gene expression, and the biochemical basis of signal desensitization and physiological adaptation, with strong emphasis on genetic and molecular analysis of these systems, especially in the yeast

MCELLBI 219U Research Review in Biochemistry and Molecular Biology: Single Molecule Biophysics 2 Units

Methods of single molecule manipulation and visualization that are used to characterize the structure and mechanochemical properties of translocating DNA binding protein such as RNA polymerase and to investigate the mechanical denaturation of single protein molecules will be covered in research reports and reviews of the current literature and in discussion of current experiments in the field.

MCELLBI 219X Research Review in Biochemistry and Molecular Biology: Cell Surface Glycoconjugate Interactions 2 Units

Investigations of cell surface glycoproteins as mediators of cell-cell interactions. Development of new methods for engineering cell surface structures.

MCELLBI 219Y Research Review in Biochemistry and Molecular Biology: Regulation of HIV Gene Expression 2 Units

Regulation of HIV gene expression by viral proteins and cellular cofactors will be covered in research reports and reviews of the current literature and in discussion of current experiments in the field.

MCELLBI 219Z Research Review in Biochemistry and Molecular Biology: Telomere Synthesis and Dynamics 2 Units

Emphasizes a study of the replication of eukaryotic telomeric DNA. Special focus on techniques in protein biochemistry and molecular biology.

MCELLBI 230 Advanced Cell Biology 4 Units

Advanced treatment of topics in cell biology.

MCELLBI 231 Advanced Developmental and Stem Cell Biology 4 Units

Principles of animal development will be set forth from the classical and recent experimental analysis of induction, localization, patterning mutants, axis formation, regional gene expression, and cell interactions. Early development of selected vertebrates and invertebrates will be examined, and emerging topics in microRNA and stem cell biology will be highlighted. A weekly discussion section with readings from the research literature is required.

MCELLBI 236 Advanced Mammalian Physiology 5 Units

Principles of mammalian (primarily human) physiology emphasizing physical, chemical, molecular, and cellular bases of functional biology. The following topics will be covered: cellular and membrane ion and nonelectrolyte transport; cell and endocrine regulation; autonomic nervous system regulation; skeletal, smooth, and cardiac muscle; cardiovascular physiology; respiration; renal physiology; gastrointestinal physiology. Discussion section will study advanced physiological topics, including: presentations by the faculty; problem sets; discussion of the primary literature and of reviews; two presentations by each student on topics in current physiological research.

MCELLBI C237 Stem Cells and Directed Organogenesis 3 Units

This course will provide an overview of basic and applied embryonic stem cell (ESC) biology. Topics will include early embryonic development, ESC laboratory methods, biomaterials for directed differentiation and other stem cell manipulations, and clinical uses of stem cells.

MCELLBI 239B Research Review in Cell and Developmental Biology: Regulation of the Cell Cycle 2 Units

Review of current literature and discussion of original research.

MCELLBI 239BB Research Review in Cell and Developmental Biology: Mechanics and Dynamics of Cell Movements 2 Units

Research in our laboratory is focused on the mechanics and dynamics of cell movements on the purified protein, single cell, and tissue levels. For these studies, we are developing new instruments to quantify cell and molecular mechanics bases on optical microscopy, force microscopy, and microfabrication.

MCELLBI 239C The Regulation of Meiotic Gene Expression and Cellular Morphogenesis 2 Units

The mechanisms that link cellular differentiation programs and dynamic gene regulation in complex eukaryotic systems remain mysterious. Such programs drive diverse and central biological processes including organismal development, immune function, disease progression, and meiosis. This course is focused on the molecular basis for the cellular remodeling accompanying meiosis, the highly conserved process by which gametes are produced.

MCELLBI 239D Research Review in Cell and Developmental Biology: Epithelial Function, Structure, and Regulations 2 Units

Review of current literature and discussion of original research.

MCELLBI 239EE Research Review in Cell and Developmental Biology: Cell Morphogenesis 2 Units

Review of current literature and discussion of original research.

MCELLBI 239F Research Review in Cell and Developmental Biology: Nucleocytoplasmic Transport 2 Units

Review of current literature and discussion of original research.

MCELLBI 239FF Research Review in Cell and Developmental Biology: Signal Transduction and Tumor Suppressor Genes 2 Units

Review of current literature and discussion of original research.

MCELLBI 239H Research Review in Cell and Developmental Biology: Cell Division 2 Units

Review of current literature and discussion of original research.

MCELLBI 239HH Research Review in Cell and Developmental Biology: Mechanisms of Control of Growth and Cell Proliferation 2 Units

Identifying pathways that restrict growth and cell proliferation in vivo.

MCELLBI 239I Research Review in Cell and Developmental Biology: Cytoskeleton and Cell Motility 2 Units

Review of current literature and discussion of original research.

MCELLBI 239J Research Review in Cell and Developmental Biology: Steroid Hormone and Growth Factor Action 2 Units

Review of current literature and discussion of original research.

MCELLBI 239K Research Review in Cell and Developmental Biology: Secretion and Cell Membrane Assembly 2 Units

Cell surface growth with emphasis on the unicellular eukaryote S. cerevisiae.

MCELLBI 239KK Research Review in Cell and Developmental Biology: Assembly and Subcellular Organization of Bacterial Organelles 2 Units

Review of current literature and discussion of original research.

MCELLBI 239M Research Review in Cell and Developmental Biology: MicroRNA Functions in Cancer Development, Mouse Tumor Models 2 Units

Malignant transformation represents the endpoint of successive genetic lesions that confer uncontrolled proliferation and survival, unlimited replicative potential, and invasive growth.

MCELLBI 239N Research Review in Cell and Developmental Biology: Biophysics of Cell Motility and Morphogenesis 2 Units

Review of current literature and discussion of original research.

MCELLBI 239O Research Review in Cell and Developmental Biology: Cancer Biology 2 Units

Inheritance, chromatin structure, gene expression, and the organization of chromosomes in the nucleus.

MCELLBI 239Q Research Review in Cell and Developmental Biology: Regulation of Cell Polarity in Drosophila 2 Units

Mechanisms underlying the establishment and maintenance of cellular organization in epithelia and other cell types.

MCELLBI 239R Research Review in Cell and Developmental Biology: Telomere Biology of Human Stem Cells 2 Units

The goal of our laboratory is to understand the key functions of telomeres and telomerase in tissue homeostasis, tumorigenesis, and aging. To this end, we generate genetically engineered human pluripotent and adult stem cell models to measure telomere and telomerase function during cellular differentiation and tumor formation.

MCELLBI 239T Research Review in Cell and Developmental Biology: The Cell Biology of Fertilization 2 Units

Research in our lab is focused on the cell biology of mammalian fertilization. Our lab uses biophysical, biochemical, and molecular genetics methods to study sperm ion channels and transporters that regulate sperm motility, chemotaxis, and the acrosome reaction. A better understanding of these processes will eventually lead to the development of effective tools to control and preserve male fertility, improve the reproductive health of human population worldwide, and advance family planning.

MCELLBI 239U Research Review in Cell and Developmental Biology: The Cytoskeleton and Morphogenesis 2 Units

Review of current literature and discussion of current research.

MCELLBI 239V Research Review in Cell and Developmental Biology: Molecular Mechanisms of Transduction in Touch and Pain Receptors 2 Units

Review of current literature and discussion of current research. Current research focuses on elucidating the molecular mechanisms of somatosensory mechanotransduction.

MCELLBI 239W Research Review in Cell and Developmental Biology: Leech Embryology and Development 2 Units

Review of current literature and discussion of original research.

MCELLBI 239X Malignant Transformation 2 Units

Malignant transformation by retroviruses and the role of protein phosphorylation in growth regulation.

MCELLBI 239Z Research Review in Cell and Developmental Biology: Chromosome Remodeling and Reorganization During Meiosis 2 Units

How chromosomes are reorganized during melosis to accomplish the pairing, recombinatin, and segregation leading up to successful gamete production.

MCELLBI 240 Advanced Genetic Analysis 4 Units

Principles and practice of classical and modern genetic analysis as applied to eukaryotic organisms, including yeast, nematodes, , mice and humans; isolation and analysis of mutations; gene mapping; suppressor analysis; chromosome structure; control of gene expression; and developmental genetics.

MCELLBI C243 Seq: Methods and Applications 3 Units

A graduate seminar class in which a group of students will closely examine recent computational methods in high-throughput sequencing followed by directly examining interesting biological applications thereof.

MCELLBI C244 Discrete Mathematics for the Life Sciences 4 Units

Introduction to algebraic statistics and probability, optimization, phylogenetic combinatorics, graphs and networks, polyhedral and metric geometry.

MCELLBI 249A Research Review in Genetics and Development: Genetics of Regulatory Variation 2 Units

Work in my group will focus on transcriptional regulatory networks and their variation between members of a species.

MCELLBI 249BB Research Review in Genetics and Development: Aging and Protein Homeostasis 2 Units

Central to the aging process is the unfolding of the proteome. Specific areas under study include cellular responses to protein misfolding and coordination of these responses across an organism.

MCELLBI 249C Research Review in Genetics and Development: Nucleic Acid-Protein Interactions and Control of Gene Expression 2 Units

Biochemical and molecular genetic aspects of eukaryotic messenger RNA splicing and transposition, with an emphasis on as an experimental system.

MCELLBI 249D Research Review in Genetics and Development: Mechanisms of Genetic Regulation in Yeast 2 Units

Genes, gene products and molecular mechanisms that control cell types in the unicellular eukaryote .

MCELLBI 249E Research Review in Genetics and Development: Molecular Genetics of <Drosophila> 2 Units

Gene regulation and developmental neurobiology.

MCELLBI 249F Research Review in Genetics and Development: Neuronal Development 2 Units

Molecular and genetic approaches to the problem of how neurons develop, with emphasis on and .

MCELLBI 249G Research Review in Genetics and Development: Developmental and Evolutionary Genetics 2 Units

We study how genes control pattern formation during development and pattern modification during evolution.

MCELLBI 249H Investigating Cellular Aging and Chromosome Segregation during Gametogenesis 2 Units

This course focuses on understanding 1) how cellular aging is affected during gametogenesis, the developmental program that produces gametes for sexual reproduction and 2) how chromosome segregation is regulated during meiosis, the specialized cell division that generates gametes.

MCELLBI 249J Research Review in Genetics and Development: Developmental and Molecular Genetics of <C. elegans> 2 Units

Molecular and genetical analysis of sex determination and dosage compensation in the nematode .

MCELLBI 249K Research Review in Genetics and Development: Animal Origins 2 Units

Evaluation of current research on choanoflagellates, sponges, and animal origins. Intended to complement ongoing research for graduate students.

MCELLBI 249L Imaging Single Molecules: Fashion or Game Changer? 2 Units

Research review in genetics, genomics and development. We will explore how the detection of single particles
(DNA, RNA, proteins) can help with understanding cellular organization and
enzymatic processes dynamics and kinetics. Most of the experiments
described will be drawn from the gene expression and nuclear organization
literature.

MCELLBI 249M Research Review in Genetics and Development: Saccharomyces Cerevisiae Microtubule Cytoskeleton 2 Units

Review of current literature and discussion of current research.

MCELLBI 249MM Physical Biology of Living Organisms 2 Units

Research review in genetics, genomics and development. In development a single cell goes through a series of repeated divisions
and these cells read the program encoded in their DNA in order to become
familiar cell types such as those found in muscle, liver, or our brains. The
goal of our lab is to uncover the rules behind these decisions with the
objective of predicting and manipulating developmental programs from just
looking at DNA sequence. In order to reach this predictive understanding we
combine physics, synthetic biology, and new technologies to query and
control developmental decisions in real time at the single cell level in
the fruit fly embryo.

MCELLBI 249N Research Review in Genetics and Development: Gene Regulation 2 Units

Current literature and research in gene regulation will be covered in research reports and reviews of the current literature and in discussion of current experiments in the field.

MCELLBI 249O Research Review in Genetics and Development: Genome Sequences 2 Units

Biochemistry, cancer biology and virology, cell biology, computational biology, genetics, microbiology, molecular and cell physiology.

MCELLBI 249P Research Review in Genetics and Development: Mesodermal Patterning and Segmentation 2 Units

Genetic, molecular, and embryological aspects of mesodermal patterning and segmentation, with emphasis on the vertebrate, zebrafish.

MCELLBI 249Q Research Review in Genetics and Development: Computational Genomics 2 Units

Recent developments in computational methods for genomics and their application for understanding the structure and function of genes encoded in completely sequenced genomes.

MCELLBI 249S Research Review in Genetics and Development: Evolution of Development Mechanisms 2 Units

Evolution of development mechanisms with a focus on the genes that regulate segmentation and regionalization of the body plan.

MCELLBI 249T Research Review in Genetics, Genomics and Development: Evolution of Genomes 2 Units

Comparative analysis of eukaryotic genomes to inform the origins and diversification of animals and plants.

MCELLBI 249U Research Review in Genetics and Development: Assembly of Eukaryotic Chromosomes 2 Units

Biochemical and genetic characterization of proteins that assemble histones onto DNA. Analysis of the relationship of chromatin assembly to DNA replication and gene expression.

MCELLBI 249V Research Review in Genetics and Development: Induction in Vertebrate Development and ES Cell Differentiation 2 Units

The Roelink laboratory is interested in the mechanisms of embryonic induction, the phenomenon in which a group of cells changes the developmental fate of neighboring cells via the release of inducers.

MCELLBI 249X Research Review in Genetics and Development: Comparative Genomics and Computational Biology 2 Units

The fundamental problem of comparative genomics: the determination of the origins and evolutionary history of the nucleotides in all extant genomes. My work incorporates various aspects of genomics, including the reconstruction of ancestral genomes (paleogenomics), the modeling of genome dynamics (phylogenomics and systems biology), and the assignment of function of genome elements (functional genomics and epigenomics).

MCELLBI 249Y Research Review in Genetics and Development: Mechanisms of Gene Control in Vertebrate Animals 2 Units

This course will focus on mechanisms of gene control in vertebrate animals, particularly in the area of vertebrate development. Amphibian egg formation, mesoderm induction, neural induction, and patterning of the nervous system at the molecular level. Control of transcription, post-transcriptional control of gene expression (including control of RNA turnover and RNA localization).

MCELLBI 249Z Research Review in Genetics and Development: Chromosome Structure and Integrity, Genome Evolution 2 Units

Use of genetic, cell biological, and biochemical approaches in budding yeast to understand genome integrity, genome evolution, and most recently desiccation tolerance.

MCELLBI 250 Advanced Immunology 4 Units

Molecular and cellular analysis of the immune response emphasizing concepts and methodology. Innate immunity, pathogen sensors, antibodies and T cell receptors, lymphocyte activation, tolerance and selection. Antigen processing, T cell subtypes, and T regulatory cells. NK cells, tumor surveillance, and AIDS.

MCELLBI 251 The Regulation of Immune System Development and Function 1 Unit

This is an advanced seminar course which will consider current research questions and experimental approaches in molecular and cellular immunology. Each registrant will present a 30-minute research talk describing the problems they are studying, the approach they are taking, their preliminary data, and technical problems. Other course participants (including basic immunology faculty) will provide criticism and suggestions.

MCELLBI 259B Research Review in Immunology and Pathogenesis: Specificity of T Lymphocytes 2 Units

Mechanisms of immune surveillance by T lymphocytes.

MCELLBI 259C Research Review in Immunology and Pathogenesis: Nuclear Receptor-Mediated Regulation of Neuroinflammation 2 Units

In this course we will discuss our research as well as recent literatures focusing on understanding of 1) How is homeostasis in the CNS regulated by innate immune functions of microglia? 2) How can we intervene in dysfunction of microglia-mediated immune functions using NRs signaling and transcription?

MCELLBI 259D Research Review in Immunology and Pathogenesis: Mycobacterial Biology and Host-Pathogen Interactions 2 Units

We will discuss macrophage biology and innate immunity in the context of infection with *Mycobacterium tuberculosis* through
discussion of current research from the Stanley Lab and both cutting edge and classic literature in relevant fields.

MCELLBI 259E Research Review in Immunology and Pathogenesis: Regulation of T Cell Receptor Genes Expression 2 Units

Molecular biology of T cell receptor genes and their transcription controlling proteins/genes. Programmed cell death during thymocyte differentiation.

MCELLBI 259F Research Review in Immunology and Pathogenesis: Natural Killer (NK) Cell and T Cell Receptors 2 Units

Molecular and biological basis for recognition by natural killer cells and T cells.

MCELLBI 259G Research Review in Immunology and Pathogenesis: T Cell Development 2 Units

Molecular and cellular aspects of thymocyte differentiation.

MCELLBI 259H Research Review in Immunology and Pathogenesis: B Cell Differentiation 2 Units

Molecular basis of terminal B cell differentiation. Role of transcription factors in B cell activation.

MCELLBI 259J Research Review in Immunology and Pathogenesis: Immune Evasion by Viruses 2 Units

The mechanisms used by viruses to counteract the pressure of the immune system.

MCELLBI 259M Research Review in Immunology and Pathogenesis: Innate Immunity and Innate Control of Adaptive Immunity 2 Units

Innate immunity and innate control of adaptive immunity.

MCELLBI 259N Research Review in Immunology and Pathogenesis: Immunology, Microbiology, and Genetics of Bacterial Pathogenesis 2 Units

Role of innate host responses in defense against intracellular bacterial pathogens.

MCELLBI C260 Introduction to Neurobiology 4 Units

An introductory course designed to provide a general understanding of the nervous system including how it functions, how it develops, and how it changes with learning and memory. Analysis from the level of molecules to cells to simple circuits to complex networks to higher brain functions.

MCELLBI C261 Advanced Cellular Neurobiology 3 Units

Physical-chemical basis of membrane potentials, electrotonus, action potential generation and propagation, synaptic transmission, sensory receptor function, and volume conductor potentials.

MCELLBI C262 Advanced Topics in Systems Neuroscience 3 Units

Advanced coverage of current research problems in systems-level neuroscience, and experimental and computational techniques used for these studies.

MCELLBI C263 Advanced Developmental Neurobiology 3 Units

Advanced level coverage of current research problems in the embryonic and post-embryonic development of invertebrate and vertebrate nervous systems.

MCELLBI 269A Research Review in Neurobiology: Special Topics in Neuroplasticity 2 Units

Molecular and cellular studies of nerve growth, axon guidance, synaptic formation, and synaptic plasticity using electrophysiological and optical imaging techniques.

MCELLBI 269B Research Review in Neurobiology: Synaptic Transmission and Neuromodulation 2 Units

Review of current literature and discussion of original research.

MCELLBI 269C Research Review in Neurobiology: Molecular Mechanisms of Neuronal Plasticity 2 Units

Research in our laboratory focuses on understanding how neurons use biochemical pathways to integrate diverse types of information in order to adjust synaptic strength and modulate neuronal excitability, and how these interactions go awry in disease. To investigate this we are taking a multi-disciplinary approach incorporating molecular, biochemical, imaging, and electrophysiological analyses in mouse and human cells.

MCELLBI 269D Research Review in Neurobiology: Signaling Within and Between Neurons 2 Units

Review of recent research in molecular mechanisms involved in intracellular and extracellular signaling in the nervous system.

MCELLBI 269F Optogenetic Dissection of Neural Circuits 2 Units

Research review in neurobiology. Review of recent optogenetic strategies for dissecting neural connectivity, function, and dysfunction in the rodent and primate brain.

MCELLBI 269H Research Review in Neurobiology: Recent Advances in Retinal Neurobiology 2 Units

Review of current literature and discussion of original research.

MCELLBI 269I Research Review in Neurobiology: Stem Cells and Gene Therapy in the Nervous System 2 Units

The basic investigation of neural differentiation of stem cells, as well as the
use of stem cells and gene delivery for neuroregeneration.

MCELLBI 269J Research Review in Neurobiology: Taste Recognition in Drosophila 2 Units

The molecular and cellular basis of taste perception in the model organism .

MCELLBI 269M Research Review in Neurobiology: Insect Neurophysiology 2 Units

Drosophila mutants that have behavioral abnormalities to unravel new and basic features of nervous system structure and function.

MCELLBI 269O Research Review in Neurobiology: Neural Circuits for Sensory Processing and Behavior 2 Units

Microcircuitry of the cerebral cortex that underlies sensory processing and adaptive behavior.

MCELLBI 269Q Research Review in Neurobiology: Sensory Processing and Plasticity in Cerebral Cortex 2 Units

How the cerebral cortex processes sensory input and stores information about the sensory world. We focus on the rat's primary somatosensory (S1) cortex.

MCELLBI 269R Research Review in Neurobiology: Potassium Channels and Synaptic Plasticity 2 Units

Review of current literature and discussion of original research.

MCELLBI 269S Research Review in Neurobiology: Molecular Mechanisms of Olfaction 2 Units

Review of current literature and discussion of original research.

MCELLBI 269T Research Review in Neurobiology: Processing of Visual Information in the Mammalian Brain 2 Units

Review of current literature and discussion of original research.

MCELLBI 269U Research Review in Neurobiology: Diseases/Retina 2 Units

Evaluation of current research in molecular mechanisms underlying diseases of the retina.

MCELLBI 269W Research Review in Neurobiology: Neural Activity Affecting the Assembly of Neural Circuits 2 Units

How neural activity affects the assembly of neural circuits.

MCELLBI 280A Selected Topics in Molecular and Cell Biology 1 Unit

The course will focus on fundamental principles, essential concepts, and recent advances in select topics in molecular and cell biology. Topics include genomics and computational biology, molecular evolution, neurons and synapses, microbi ology and immunology, macromolecular structure and function, and scientific writing. Courses are taught in tandem and maybe taken individually.

MCELLBI 280B Selected Topics in Molecular and Cell Biology 1 Unit

The course will focus on fundamental principles, essential concepts, and recent advances in select topics in molecular and cell biology. Topics include genomics and computational biology, molecular evolution, neurons and synapses, microbi ology and immunology, macromolecular structure and function, and scientific writing. Courses are taught in tandem and maybe taken individually.

MCELLBI 280C Selected Topics in Molecular and Cell Biology 1 Unit

The course will focus on fundamental principles, essential concepts, and recent advances in select topics in molecular and cell biology. Topics include genomics and computational biology, molecular evolution, neurons and synapses, microbi ology and immunology, macromolecular structure and function, and scientific writing. Courses are taught in tandem and maybe taken individually.

MCELLBI 280D Selected Topics in Molecular and Cell Biology 1 Unit

The course will focus on fundamental principles, essential concepts, and recent advances in select topics in molecular and cell biology. Topics include genomics and computational biology, molecular evolution, neurons and synapses, microbi ology and immunology, macromolecular structure and function, and scientific writing. Courses are taught in tandem and maybe taken individually.

MCELLBI 280E Selected Topics in Molecular and Cell Biology 1 Unit

The course will focus on fundamental principles, essential concepts, and recent advances in select topics in molecular and cell biology. Topics include genomics and computational biology, molecular evolution, neurons and synapses, microbi ology and immunology, macromolecular structure and function, and scientific writing. Courses are taught in tandem and maybe taken individually.

MCELLBI 280F Selected Topics in Molecular and Cell Biology 1 Unit

The course will focus on fundamental principles, essential concepts, and recent advances in select topics in molecular and cell biology. Topics include genomics and computational biology, molecular evolution, neurons and synapses, microbi ology and immunology, macromolecular structure and function, and scientific writing. Courses are taught in tandem and maybe taken individually.

MCELLBI 290 Graduate Seminar 1 Unit

Graduate student presentations on selected research topics in molecular and cell biology. Several sections covering different topics offered each semester. Concurrent enrollment in more than one section is permitted. List of topics to be announced before each semester.

MCELLBI 291A Introduction to Research 2 - 12 Units

Closely supervised experimental work under the direction of an individual faculty member; an introduction to experimental methods and research approaches in particular areas of molecular and cell biology.

MCELLBI 291B Introduction to Research 2 - 12 Units

Closely supervised experimental work under the direction of an individual faculty member; an introduction to experimental methods and research approaches in particular areas of molecular and cell biology.

MCELLBI 292 Research 3 - 12 Units

Individual research under the supervision of a faculty member.

MCELLBI N292 Research 3 - 6 Units

Individual research under the supervision of a staff member.

MCELLBI 293A Research Seminar 2 Units

Seminar on presentation and evaluation of results in area of student's individual research interests.

MCELLBI 293C Responsible Conduct of Research 1 Unit

This course will cover topics in responsible conduct in research drawing from case studies of the Association of American Medical Colleges and the NIH. Students will review case studies in preparation for class discussion. Required of all MCB graduate and post doctoral students funded on NIH training grants. One session will probably feature a guest lecturer on a topic relevant to the course.

MCELLBI 295 Careers for Life Sciences Ph.D's 1 Unit

This course is designed to assist graduate students in the biological sciences with planning their postgraduate careers. Weekly guest speakers will present their experiences on a variety of topics. Postdoctoral students are invited. Topics may include academia; job searches; setting up a laboratory; patent law/technology transfer; public policy/regulatory affairs; bioinformatics; science writing/technical support; forensic science; postdoctoral positions in industry; teaching, and other topics of interest.

MCELLBI 380 Teaching of Molecular and Cell Biology 1 - 2 Units

Teaching laboratories and/or discussions for Molecular and Cell Biology courses: analysis of specific format and problems. Two units of credit for those with 50% teaching appointment; one unit of credit for those with 25% teaching appointment.

MCELLBI 481B Instrumentation in Molecular and Cell Biology: Transmission Electron Microscopy 1 - 4 Units

Individualized laboratory instruction.

MCELLBI 481C Instrumentation in Molecular and Cell Biology: Scanning Electron Microscopy 1 - 4 Units

Individualized laboratory instruction.

MCELLBI 601 Individual Study for Master's Students 1 - 8 Units

Individual study for the comprehensive or language examinations in consultation with the field adviser.

MCELLBI 602 Individual Study for Doctoral Students 1 - 8 Units

Individual study in consultation with the major field adviser. Intended to provide an opportunity for qualified students to prepare themselves for the various examinations required of candidates for the Ph.D.

Faculty

Professors

Georjana Barnes, Professor. Biochemistry, genetics, cancer, biology, microtubule cytoskeleton, cell cycle controls, cellular imaging.
Research Profile

James M. Berger, Professor. Structural & mechanistic biochemistry of macromolecular assemblies & machines, multiprotein complexes; DNA replication, maintenance of chromosome superstructure;catalytic mechanism & enzyme/small-molecule inhibitor studies.
Research Profile

David Bilder, Professor. Genetics, cancer, Drosophila, cell biology, cell polarity, tumor suppressor, epithelial architecture, polarity, and proliferation control.
Research Profile

W. Zacheus Cande, Professor. Genetics, cell biology, microbial biology, plant biology.
Research Profile

Jamie H. D. Cate, Professor. Molecular basis for protein synthesis by the ribosome, RNA, antibiotics, a thermophilic bacterium, escherichia coli.
Research Profile

Kathleen Collins, Professor. RNA, telomerase, Telomere function, Telomere replication.
Research Profile

Yang Dan, Professor. Neuronal circuits, mammalian visual system, electrophysiological, psychophysical and computational techniques, visual cortical circuits, visual neurons.
Research Profile

Abby Dernburg, Professor. Genomics, chromosome remodeling and reorganization during meiosis, Down syndrome, DNA.
Research Profile

Andrew Dillin, Professor.

Jennifer A Doudna, Professor. RNA machines, hepatitis C virus, RNA interference, ribosomes.
Research Profile

David G. Drubin, Professor. Cellular morphogenesis, plasma membrane dynamics, microtubule cytoskeletons, cytoskeletal proteins, morphological development.
Research Profile

Peter H. Duesberg, Professor. Genetic structure of retroviruses, carcinogenesis, aneuploidy, virology, HIV-AIDS.
Research Profile

Michael B. Eisen, PhD, Professor. Genomics, genome sequencing, bioinformatics, animal development.
Research Profile

Marla B. Feller, Professor. Neurophysiology, developmental neuroscience.
Research Profile

Gary L. Firestone, Professor. Cancer, steroid hormones, molecular endocrinology, tumor biology, growth factors, dietary compounds, tumor cells, glucocorticoids.
Research Profile

Gian Garriga, Professor. Developmental neurobiology; molecular genetics, development of nervous systems, cell division, cell migration, axonal pathfinding, caenorhabditis elegans.
Research Profile

Iswar Krishna Hariharan, Professor.

Rebecca Heald, Professor. Cell division, Xenopus, mitotic spindle assembly and function, size control of intracellular structures.
Research Profile

James H Hurley, Professor.

Ehud Y. Isacoff, Professor. Ion channel function, synaptic plasticity, neural excitability, synaptic transmission, the synapse.
Research Profile

Douglas E. Koshland, Professor. Higher order chromosome structure, genome integrity, sister chromatid cohesion, chromosome condensation, desiccation tolerance, microbial genetics.
Research Profile

Richard H Kramer, Professor. Cells, synaptic transmission, chemical signaling between neurons, ion channels, electrical signals, chemical reagents, synapses.
Research Profile

John Kuriyan, Professor. Structural and functional studies of signal transduction, DNA replication, cancer therapies, phosphorylation.
Research Profile

Michael S Levine, Professor. Regulation of enhancer-promoter interactions, gene networks, animal development and disease, drosophila embryo, immune response in drosophila larvae, differentiation of the notochord and heart in the sea squirt, whole-genome analysis.
Research Profile

Kunxin Luo, Professor. Signal transduction pathways, mechanisms controlling the receptor kinases, regulation of mammary epithelial cell differentiation, breast carcinogenesis.
Research Profile

Terry E. Machen, PhD, Professor. Physiology pathophysiology secretory epithelial cells, airway, ion transport, cell regulationm, imaging microscopy, calcium pH redox, electrophysiology, green fluorescent protein, genetic targeting, innate immune defense.
Research Profile

Susan Marqusee, Professor. Amino acids, determinants of protein structure and folding, biophysical, structural and computational techniques, translocation, protein synthesis.
Research Profile

Barbara J Meyer, Professor. Developmental biology, gene expression, genetic determination of sex, regulatory genes, chromosome dynamics, X-chromosome.
Research Profile

John Ngai, Professor. Nervous system, molecular and cellular mechanisms of olfaction, detection of odors, odorant receptors, olfactory neurons, DNA microarray technologies, genome-wide patterns of gene expression.
Research Profile

Nipam Patel, Professor. Genetics, evolution, crustaceans, insects, arthropods, homeotic (Hox) genes, segmentation, embryonic pattern formation, neural patterning.
Research Profile

Mu-Ming Poo, Professor. Neurobiology, cellular and molecular mechanisms, axon guidance, synapse formation, activity-dependent refinement of neural circuits.
Research Profile

Michael P Rape, PhD, Professor. Cancer, protein degradation, siRNA, Berkeley Screening Center.
Research Profile

Jasper D. Rine, Professor. Biology, cell biology, DNA replication, gene regulation, saccharomyces cerevisiae, genetic analysis, genome, cholesterol biosynthetic pathway, modification of proteins, prenylated proteins.
Research Profile

Donald C. Rio, Professor. Molecular genetics, drosophila melanogaster, transposable elements, RNA splicing, nucleic acid rearrangement reactions, P elements and their cellular host, HIV, proteomic diversification, nucleoprotein complexes.
Research Profile

Ellen Robey, Professor. Fate determination in the T-lymphocyte lineage, T cell development in the mouse, thymic development, cellular maturation, parasitic infection, chronic infection, host-pathogen interactions, Toxoplasma gondii.
Research Profile

Randy W Schekman, Professor. Saccharomyces cerevisiae, organelle assembly, intracellular protein transport, assembly of cellular organelles, Alzheimer's Disease.
Research Profile

Kristin Scott, Professor. Nerve cell connectivity in developing nervous systems, taste perception in the fruit fly, taste neural circuits, sensory maps in the brain.
Research Profile

Karsten Weis, Professor. Molecular biology, proteins, macromolecular transport, nucleus of eukaryotic cells, DNA transcription, mRNA translation, nuclear pore complex, the cytoplasm, cerevisiae and metazoan cells, transport of macromolecules, the cell cycle.
Research Profile

David A. Weisblat, Professor. Developmental biology, glossiphoniid leech embryos, evolution of different animal taxa, microinjection of cell lineage tracers.
Research Profile

Matthew D. Welch, Professor. Biology, cell motility, the role of the actin cytoskeleton in cell locomotion, shape change, actin filament assembly, bacterial and viral pathogens.
Research Profile

Astar Winoto, PhD, Professor. Cancer, genomics, apoptosis, innate immunity and infectious diseases, cell cycle, signal transduction, immune tolerance.
Research Profile

Qiang Zhou, PhD, Professor. Biochemistry of HIV gene expression, transcriptional elongation, Tat activation, stage of transcriptional elongation, HIV replication, anti-HIV therapy.
Research Profile

Associate Professors

Gregory M. Barton, Associate Professor. Immunology, cell biology, infectious disease, innate immunity.
Research Profile

Laurent Coscoy, Associate Professor. Immunology, viruses, viral infection, immune responses, immune evasion.
Research Profile

Dan Feldman, PhD, Associate Professor. Neurobiology, learning, neurophysiology, sensory biology.
Research Profile

Nicole King, Associate Professor. Genetics, developmental biology, biology, choanoflagellates, evolution of multicellular animals, comparative genomics, molecular phylogenetics, eukaryotes, cadherins, host-microbe interactions.
Research Profile

Henk Roelink, PhD, Associate Professor. Stem cells, neural development, embryonic induction.
Research Profile

Bill Sha, Associate Professor. B cell gene regulation, fate determination, gene regulatory pathways, antibody-secreting plasma cells, memory B cells, apoptotic cells, B7 costimulatory ligands.
Research Profile

Russell E. Vance, Associate Professor. Immunology, microbiology, infectious disease, molecular and cell biology.
Research Profile

Assistant Professors

Hillel Adesnik, Assistant Professor.

Helen Bateup, Assistant Professor.

Diana Bautista, PhD, Assistant Professor. Ion channels, sensory physiology, chemosensation, touch, thermosensation, somatosensory system.
Research Profile

Gloria A Brar, PhD, Assistant Professor.

Rachel B Brem, Assistant Professor. Genetics of regulatory variation.
Research Profile

Lin He, Assistant Professor.

Dirk Hockemeyer, Assistant Professor.

Nicholas Ingolia, PhD, Assistant Professor.

Bryan A. Krantz, PhD, Assistant Professor. Protein folding, spectroscopy, electrophysiology, biophysical studies of transmembrane protein translocation, microbial toxins.
Research Profile

Polina V Lishko, PhD, Assistant Professor.

Craig T. Miller, PhD, Assistant Professor. Genetics, developmental biology, evolutionary biology, evolution, quantitative genetics, developmental genetics, evolutionary genetics, craniofacial development.
Research Profile

Kaoru Saijo, Assistant Professor.

David Savage, PhD, Assistant Professor. Synthetic biology and metabolism.
Research Profile

Elcin Unal, Assistant Professor.

Roberto Zoncu, PhD, Assistant Professor.

Adjunct Faculty

Gary H. Karpen, Adjunct Faculty. Gene expression, cell biology, chromosome structure and function, drosophila melanogaster, centromere identity and function.
Research Profile

Robert T. Tjian, Adjunct Faculty. Eukaryotic molecular biology; biochemistry, cellular differentiation, chromatin function, RNA synthesis.
Research Profile

Lecturers

P. Robert Beatty, Lecturer.

Helen Lew, PhD, Lecturer.

David E. Presti, Lecturer.

Gary Joseph Wedemayer, Lecturer.

Contact Information

Department of Molecular and Cell Biology

142 Life Sciences Addition

Phone: 510-642-2651

Visit Department Website

Department Co-Chair

David Raulet, PhD

481A Life Sciences Addition

Phone: 510-642-9521

raulet@berkeley.edu

Department Co-Chair

Richard Harland, PhD

571A Life Sciences Addition

Phone: 510-643-9872

harland@berkeley.edu

Neurobiology Division Chair

Marla Feller, PhD

195A Life Sciences Addition

Phone: 510-643-1726

mfeller@berkeley.edu

Chair, Undergraduate Affairs Committee

Eva Nogales

708C Stanley Hall

Phone: 510-642-0557

enogalel@lbl.gov

Undergraduate Advising Office Manager

Jessica Kongthong

Phone: 510-643-7473

jesskt@berkeley.edu

Undergraduate Affairs Manager

James Depelteau, MA

3060 Valley Life Sciences Building

Phone: 510-643-8895

jdepelteau@berkeley.edu

Undergraduate Staff Adviser

Anwar Thomas, MA

3060 Valley Life Sciences Building

Phone: 510-643-8895

anwar.thomas@berkeley.edu

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